Higher dietary insulin index is directly associated with the odd of kidney stones

被引：0
作者：
Maddahi, Niloofar Sadat [1 ,2 ]
Fotros, Danial [3 ]
Sohouli, Mohammad Hassan [3 ]
Mozaffari-Khosravi, Hassan [1 ,2 ]
Khayyatzadeh, Sayyed Saeid [1 ,2 ]
机构：
[1] Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd, Iran
[2] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, POB 8915173160, Yazd, Iran
[3] Shahid Beheshti Univ Med Sci, Student Res Comm, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran
来源：
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词：
Nephrolithiasis; Kidney stones; Dietary insulin load; Dietary insulin index; Hyperinsulinemia; RENAL AMMONIAGENESIS; METABOLIC SYNDROME; RISK; NEPHROLITHIASIS; PATHOPHYSIOLOGY; VEGETABLES; RESISTANCE; COHORT; LOAD; RAT;
D O I：
10.1038/s41598-024-79419-7
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Kidney stones or Nephrolithiasis are the most common health condition associated with the urinary system. Dietary factors stand as important factors in the occurrence and development of kidney stones. This study aimed to examine the potential link between dietary insulin index (DII) and dietary insulin load (DIL) with prevalence of kidney stones. This cross-sectional study was conducted among adults aged 30 to 75 years in the Shahedieh district of Yazd, Iran, over the period of 2015-2016. DII and DIL were calculated using a validated semi-quantitative food-frequency questionnaire and mathematical formula. Diagnosis of kidney stones is made on the basis of information obtained from self-reported questionnaire (Yes/ No). To explore the association between DII and DIL with the odds of kidney stones, logistic regression was employed in crude and adjusted models. A total of 4,829 participants were included in this study. Individuals in the last quartile of DIL had 214% higher odds of kidney stones in the crude model (OR: 2.14, 95% CI: 1.62-2.83; P-trend < 0.001); this association was remained significant after adjustments for confounding variables (OR: 1.44, 95% CI: 1.04-1.97; P-trend: 0.019). There was a direct significant relationship between DII and odds of kidney stones among third and forth quartiles of DII (OR: 1.52, 95% CI: 1.16-1.98, P-trend = 0.002); but this association disappeared for adjusted models. Higher DII and DIL were associated with an increased odd of renal stones. Large longitudinal study is required to clarify these associations.
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页数：10
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