Influence of Sodium and Silver Salts of Pyrrolopyrazoles on Innate Immunity Reactions In Vivo

被引：0

作者：

Gein, S. V. ^{[1
]}

Bobrovskaya, O. V. ^{[2
]}

Makarov, E. A. ^{[1
]}

Gein, V. L. ^{[2
]}

机构：

[1] Russian Acad Sci, Inst Ecol & Genet Microorganisms, Fed Res Ctr, Ural Branch,Branch Perm, 13 Goleva St, Perm 614990, Russia

[2] Minist Hlth Russian Federat, Perm State Pharmaceut Acad, 2 Polevaya St, Perm 614990, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2025年 / 58卷 / 11期

关键词：

sodium and silver salts of pyrrolo[3,4-c]pyrazol-3-ones; phagocytosis; oxygen radicals; leukocytes; ANTIINFLAMMATORY ACTIVITY;

D O I：

10.1007/s11094-025-03322-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven compounds were studied in this work: three sodium salts of pyrrolo[3,4-c]pyrazol-3-ones (Ia-c) and four silver salts of pyrrolo[3,4-c]pyrazol-3-ones (IIa-d). Compound Ia was found to enhance the spontaneous and stimulated production of reactive oxygen species by peritoneal leukocytes. Compound Ic also had an activating effect on stimulated luminol-dependent chemiluminescence (LDCL). An assessment of the effect of sodium salts of pyrrolopyrazoles on phagocytosis activity showed a stimulating effect of Ia on the percentage of phagocytosis of peritoneal leukocytes. Silver salts of pyrrolopyrazoles had an opposite effect on the dynamics of the oxidative burst and phagocytic activity. Compound IId was found significantly to inhibit both spontaneous and simulated production of oxygen radicals. In addition, compounds IIa and IIc had a less pronounced inhibitory effect on stimulated LDCL. Compound IId statistically significantly reduced the percentage of phagocytosis of peritoneal phagocytes.

引用

页码：1679 / 1684

页数：6

共 22 条

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