Loneliness and susceptibility to social pain mediate the association between autistic traits and psychotic experiences in young non-clinical adults

被引：0

作者：

Fekih-Romdhane, Feten ^{[1
,2
]}

Chaibi, Leila Sarra ^{[1
]}

Alhuwailah, Amthal ^{[3
]}

Sakr, Fouad ^{[4
]}

Helmy, Mai ^{[5
]}

Ahmed, Hanaa ^{[1
]}

Shuwiekh, Mohamed ^{[6
,7
]}

Boudouda, Nedjem Eddine ^{[8
]}

Zarrouq, Btissame ^{[9
]}

Naser, Abdallah Y. ^{[10
]}

Jebreen, Kamel ^{[11
,12
]}

Roubi, Mohammed Lakhdar ^{[13
]}

Hassan, Abdul Rasool Bassam ^{[14
]}

Merdad, Nisma ^{[15
]}

Amin, Rizwana ^{[15
]}

Nawajah, Inad ^{[16
]}

Mohammed, Ali Haider ^{[17
]}

Farhan, Sinan Subhi ^{[18
]}

Alani, Omar Abdulwahid ^{[14
]}

Dabbous, Mariam ^{[3
]}

Malaeb, Diana ^{[19
]}

Obeid, Sahar ^{[20
]}

Loch, Alexandre Andrade ^{[21
,22
]}

Cheour, Majda ^{[1
,2
]}

Hallit, Souheil ^{[15
,23
,24
]}

机构：

[1] Tunis El Manar Univ, Fac Med Tunis, Tunis, Tunisia

[2] Razi Hosp, Tunisian Ctr Early Intervent Psychosis, Dept Psychiat Ibn Omrane, Tunis, Tunisia

[3] Kuwait Univ, Dept Psychol, Kuwait, Kuwait

[4] Lebanese Int Univ, Sch Pharm, Beirut, Lebanon

[5] Sultan Qaboos Univ, Coll Educ, Psychol Dept, Muscat, Oman

[6] Fayoum Univ, Dept Anaesthesiol, Faiyum, Egypt

[7] Badr Univ Cairo BUC, Cairo, Egypt

[8] Univ 8 Mai 1945, Guelma, Algeria

[9] Sidi Mohammed Ben Abdellah Univ, Fac Med & Pharm, Lab epidemiol & Res Hlth Sci, Fes, Morocco

[10] Isra Univ, Fac Pharm, Dept Appl Pharmaceut Sci & Clin Pharm, Amman, Jordan

[11] Palestine Tech Univ Kadoorie, Dept Math, P-766 Hebron, Palestine

[12] Annajah Natl Univ, Dept Bldg Engn, P-400 Nablus, Palestine

[13] Univ Bahrain, Coll Arts, Dept Social Sci, POB 32038, Sakhir, Bahrain

[14] Al Rafidain Univ Coll, Dept Pharm, Baghdad, Iraq

[15] Effat Univ, Coll Humanities, Psychol Dept, Jeddah 21478, Saudi Arabia

[16] Hebron Univ, Coll Sci & Technol, Dept Math, Hebron, Palestine

[17] Monash Univ Malaysia, Sch Pharm, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia

[18] Al Rafidain Univ Coll, Dept Anesthesia Tech, Baghdad, Iraq

[19] Gulf Med Univ, Coll Pharm, Ajman, U Arab Emirates

[20] Lebanese Amer Univ, Sch Arts & Sci, Social & Educ Sci Dept, Jbeil, Lebanon

[21] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Lab Neurociencias LIM 27, Sao Paulo, SP, Brazil

[22] Conselho Nacl Desenvolvimento Cient & Tecnol, Inst Nacl Biomarcadores Neuropsiquiatria INB, Sao Paulo, Brazil

[23] Holy Spirit Univ Kaslik USEK, Sch Med & Med Sci, POB 446, Jounieh, Lebanon

[24] Appl Sci Private Univ, Appl Sci Res Ctr, Amman, Jordan

来源：

SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期

关键词：

Autistic traits; Psychotic experiences; Loneliness; Social pain; Mediation; Adults; General population; SCHIZOTYPAL PERSONALITY-TRAITS; PRODROMAL QUESTIONNAIRE; CULTURAL-DIFFERENCES; SPECTRUM DISORDERS; HIGH-RISK; SCHIZOPHRENIA; EXCLUSION; CHILDHOOD; CHILDREN; SELF;

D O I：

10.1038/s41598-025-90597-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Understanding of the mechanisms involved in the occurrence of psychotic experiences (PEs) in highly autistic individuals is crucial for identifying appropriate prevention and intervention strategies. This study aimed to investigate the mediating role of susceptibility to social pain and loneliness in the relationship between autistic traits (ATs) and PEs in adults from the general population of 12 Arab countries. This cross-sectional study is part of a large-scale multi-country research project. A total of 7646 young adults (age range 18-35 years, mean age of 22.55 +/- 4.00 years and 75.5% females) from twelve Arab countries (i.e., Algeria, Bahrain, Egypt, Iraq, Jordan, Kingdom of Saudi Arabia, Kuwait, Lebanon, Morocco, Oman, Palestine, and Tunisia) were included. Mediation analyses showed that, after adjusting over confounding variables, both loneliness (indirect effect: Beta = 0.18; Boot SE = 0.02; Boot CI 0.14; 0.21) and social pain (indirect effect: Beta = 0.03; Boot SE = 0.01; Boot CI 0.001; 0.05) partially mediated the association between ATs and PEs. Higher ATs were significantly associated with more loneliness and susceptibility to social pain, and directly associated with more severe PEs. Finally, higher loneliness and susceptibility to social pain were significantly associated with greater PEs scores. Findings indicated that individuals with higher ATs tend to experience greater loneliness and feel more pain from rejection, which can in turn be associated with higher levels of PEs. Interventions targeting susceptibility to social pain and loneliness as a means of mitigating PEs among highly autistic adults should be considered.

引用

页数：13

共 98 条

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