Unveiling therapeutic avenues targeting xCT in head and neck cancer

被引：0
作者：
Lee, Jaewang [1 ]
Roh, Jong-Lyel [1 ,2 ]
机构：
[1] CHA Univ, CHA Bundang Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Seongnam 13496, Gyeonggi Do, South Korea
[2] CHA Univ, Gen Grad Sch, Dept Biomed Sci, Pochon, South Korea
来源：
CELLULAR ONCOLOGY | 2024年 / 47卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
xCT; Ferroptosis; Head and neck cancer; Resistance; Therapy; REGULATES FERROPTOSIS; CISPLATIN RESISTANCE; TUMOR PROGRESSION; CIRCULAR RNAS; CELL-DEATH; METABOLISM; PATHWAY; NRF2; TRANSPORTER; EXPRESSION;
D O I：
10.1007/s13402-024-00997-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Head and neck cancer (HNC) remains a major global health burden, prompting the need for innovative therapeutic strategies. This review examines the role of the cystine/glutamate antiporter (xCT) in HNC, specifically focusing on how xCT contributes to cancer progression through mechanisms such as redox imbalance, ferroptosis, and treatment resistance. The central questions addressed include how xCT dysregulation affects tumor biology and the potential for targeting xCT to enhance treatment outcomes. We explore recent developments in xCT-targeted current and emerging therapies, including xCT inhibitors and novel treatment modalities, and their role in addressing therapeutic challenges. This review aims to provide a comprehensive analysis of xCT as a therapeutic target and to outline future directions for research and clinical application.
引用
收藏
页码：2019 / 2030
页数：12
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