Unveiling therapeutic avenues targeting xCT in head and neck cancer

被引：0
作者：
Lee, Jaewang [1 ]
Roh, Jong-Lyel [1 ,2 ]
机构：
[1] CHA Univ, CHA Bundang Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Seongnam 13496, Gyeonggi Do, South Korea
[2] CHA Univ, Gen Grad Sch, Dept Biomed Sci, Pochon, South Korea
来源：
CELLULAR ONCOLOGY | 2024年 / 47卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
xCT; Ferroptosis; Head and neck cancer; Resistance; Therapy; REGULATES FERROPTOSIS; CISPLATIN RESISTANCE; TUMOR PROGRESSION; CIRCULAR RNAS; CELL-DEATH; METABOLISM; PATHWAY; NRF2; TRANSPORTER; EXPRESSION;
D O I：
10.1007/s13402-024-00997-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Head and neck cancer (HNC) remains a major global health burden, prompting the need for innovative therapeutic strategies. This review examines the role of the cystine/glutamate antiporter (xCT) in HNC, specifically focusing on how xCT contributes to cancer progression through mechanisms such as redox imbalance, ferroptosis, and treatment resistance. The central questions addressed include how xCT dysregulation affects tumor biology and the potential for targeting xCT to enhance treatment outcomes. We explore recent developments in xCT-targeted current and emerging therapies, including xCT inhibitors and novel treatment modalities, and their role in addressing therapeutic challenges. This review aims to provide a comprehensive analysis of xCT as a therapeutic target and to outline future directions for research and clinical application.
引用
收藏
页码：2019 / 2030
页数：12
相关论文
共 50 条
  • [31] EGFR pathway targeting drugs in head and neck cancer in the era of immunotherapy
    Kang, James J.
    Ko, Albert
    Kil, Sang Hoon
    Clair, Jon Mallen-St.
    Shin, Daniel Sanghoon
    Wang, Marilene B.
    Srivatsan, Eri S.
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023, 1878 (01):
  • [32] SLC7A11/xCT in cancer: biological functions and therapeutic implications
    Lin, Wenyu
    Wang, Chaoqun
    Liu, Guangping
    Bi, Chao
    Wang, Xian
    Zhou, Qiyin
    Jin, Hongchuan
    AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 10 (10): : 3106 - 3126
  • [33] Development of a rational strategy for integration of lactate dehydrogenase A suppression into therapeutic algorithms for head and neck cancer
    Chen, Yunyun
    Maniakas, Anastasios
    Tan, Lin
    Cui, Meng
    Le, Xiangdong
    Niedzielski, Joshua S.
    Michel, Keith A.
    Harlan, Collin J.
    Lu, Wuhao
    Henderson, Ying C.
    Mohamed, Abdallah S. R.
    Lorenzi, Philip L.
    Putluri, Nagireddy
    Bankson, James A.
    Sandulache, Vlad C.
    Lai, Stephen Y.
    BRITISH JOURNAL OF CANCER, 2021, 124 (10) : 1670 - 1679
  • [34] Biomarkers of head and neck cancer stem cells and targeted therapeutic strategies
    Shen, Li-Fang
    Zhou, Min-Li
    Zhou, Shui-Hong
    Bao, Yang-Yang
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 9 (02): : 614 - 625
  • [35] Targeting EGFR resistance networks in head and neck cancer
    Ratushny, Vladimir
    Astsaturov, Igor
    Burtness, Barbara A.
    Golemis, Erica A.
    Silverman, Joshua S.
    CELLULAR SIGNALLING, 2009, 21 (08) : 1255 - 1268
  • [36] Epigenetic Targeting to Overcome Radioresistance in Head and Neck Cancer
    Schniewind, Inaki
    Besso, Maria Jose
    Klicker, Sebastian
    Schwarz, Franziska Maria
    Hadiwikarta, Wahyu Wijaya
    Richter, Susan
    Lock, Steffen
    Linge, Annett
    Krause, Mechthild
    Dubrovska, Anna
    Baumann, Michael
    Kurth, Ina
    Peitzsch, Claudia
    CANCERS, 2024, 16 (04)
  • [37] Iron, Ferroptosis, and Head and Neck Cancer
    Teng, Yong
    Gao, Lixia
    Makitie, Antti A.
    Florek, Ewa
    Czarnywojtek, Agata
    Saba, Nabil F.
    Ferlito, Alfio
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (20)
  • [38] A comprehensive review of current therapeutic strategies in cancers targeting DNA damage response mechanisms in head and neck squamous cell cancer
    Kono, Takeyuki
    Ozawa, Hiroyuki
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2025, 1880 (01):
  • [39] Targeted therapy in head and neck cancer
    Bianchini, Chiara
    Ciorba, Andrea
    Pelucchi, Stefano
    Piva, Roberta
    Pastore, Antonio
    TUMORI, 2011, 97 (02) : 137 - 141
  • [40] Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer
    Kartha, Vinay K.
    Alamoud, Khalid A.
    Sadykov, Khikmet
    Nguyen, Bach-Cuc
    Laroche, Fabrice
    Feng, Hui
    Lee, Jina
    Pai, Sara I.
    Varelas, Xaralabos
    Egloff, Ann Marie
    Snyder-Cappione, Jennifer E.
    Belkina, Anna C.
    Bais, Manish V.
    Monti, Stefano
    Kukuruzinska, Maria A.
    GENOME MEDICINE, 2018, 10
12345