A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy

被引：1

作者：

Song, Feifei ^{[1
]}

Dotti, Gianpietro ^{[1
]}

机构：

[1] Univ North Carolina, Chapel Hill, NC 27514 USA

来源：

NATURE IMMUNOLOGY | 2025年 / 26卷 / 02期

关键词：

D O I：

10.1038/s41590-024-02049-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In an unbiased high-throughput screen of 800 kinase inhibitors, we identified a cocktail of kinase inhibitors that increase the frequency of T memory stem cells for CAR-T cell therapy, resulting in improved antitumor effects both in vitro and in mouse models.

引用

页码：170 / 171

页数：2

共 5 条

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