Organoid, organ-on-a-chip and traditional Chinese medicine

被引：0
作者：
Yang, Jiayue [1 ]
Jiang, Yu [2 ]
Li, Mingxing [1 ,3 ]
Wu, Ke [1 ]
Wei, Shulin [1 ]
Zhao, Yueshui [1 ,3 ]
Shen, Jing [1 ,3 ]
Du, Fukuan [1 ,3 ]
Chen, Yu [1 ,3 ]
Deng, Shuai [1 ,3 ]
Xiao, Zhangang [1 ,3 ,4 ,5 ]
Yuan, Wen [5 ]
Wu, Xu [1 ,6 ]
机构：
[1] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Cell Therapy & Cell Drugs Luzhou Key Lab, Luzhou 646000, Peoples R China
[2] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Dept Gerontol, Luzhou 646000, Peoples R China
[3] South Sichuan Inst Translat Med, Luzhou 646000, Peoples R China
[4] Gulin Cty Hosp Tradit Chinese Med, Luzhou 646500, Peoples R China
[5] Sichuan Coll Tradit Chinese Med, Sch Pharm, Mianyang 621000, Sichuan, Peoples R China
[6] Luzhou Peoples Hosp, Dept Paediat & Paediat Care, Luzhou 646000, Sichuan, Peoples R China
来源：
CHINESE MEDICINE | 2025年 / 20卷 / 01期
关键词：
Traditional Chinese medicine; Organoids; Organ-on-a-chip; Co-culture; BRAIN ORGANOIDS; GASTRIC-CANCER; CELLS; GENERATION; APOPTOSIS; STRATEGY; PLATFORM; PROGRESS; COLITIS; MODELS;
D O I：
10.1186/s13020-025-01071-8
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
In the past few years, the emergence of organoids and organ-on-a-chip (OOAC) technologies, which are complementary to animal models and two-dimensional cell culture methods and can better simulate the internal environment of the human body, provides a new platform for traditional Chinese medicine (TCM) studies. Organoids and OOAC techniques have been increasingly applied in the fields of drug screening, drug assessment and development, personalized therapies, and developmental biology, and there have been some application cases in the TCM studies. In this review, we summarized the current status of using organoid and OOAC technologies in TCM research and provide key insights for future study. It is believed that organoid and OOAC technologies will play more and more important roles in research and make greater contributions to the innovative development of TCM.
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页数：19
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