Serum hemoglobin and albumin levels serve as prognostic predictors after adrenal metastasectomy

被引：0
作者：
Ma, Nan [1 ,2 ]
He, Xiaobo [2 ]
Nei, Qiwei [3 ]
Liu, Zhenhua [1 ,2 ]
Chen, Xianda [1 ,2 ]
Chang, Hui [2 ,4 ]
Yao, Kai [1 ,2 ]
Guo, Shengjie [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Canc Ctr, Dept Urol, Guangzhou 510060, Peoples R China
[2] Sun Yat Sen Univ, Guangdong Prov Clin Res Ctr Canc, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China,Canc Ctr, Guangzhou 510060, Peoples R China
[3] Jinan Univ, Zhuhai Hosp, Dept Urol, Zhuhai 519000, Peoples R China
[4] Sun Yat Sen Univ, Dept Radiat Oncol, Canc Ctr, Guangzhou 510060, Peoples R China
来源：
DISCOVER ONCOLOGY | 2024年 / 15卷 / 01期
关键词：
Adrenal metastasectomy; Hemoglobin; Albumin; Prognosis; CELL LUNG-CANCER; GASTRIC-CANCER; OUTCOMES; SURVIVAL; HYPOXIA;
D O I：
10.1007/s12672-024-01647-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PurposeAdrenal metastasectomy is a common local treatment for adrenal metastases, with a lack of serum prognostic factors. Here, we identified the prognostic significance of preoperative hemoglobin and albumin levels in patients undergoing adrenal metastasectomy.Materials and MethodsData from 93 patients who underwent adrenal metastasectomy were assessed retrospectively. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal cutoff values of hemoglobin and albumin for survival. Overall survival (OS) and disease-free survival (DFS) were evaluated using the Kaplan-Meier method, thereafter Cox regression models and subgroup analyses were applied to adjust confounding factors. A risk stratification developed by joint use of serum hemoglobin and albumin levels was also tested.ResultsOptimal cut-off points were 130.5 g/L and 44.8 g/L for hemoglobin and albumin, respectively. Multivariate Cox regression analysis identified decreased hemoglobin (HR [95% CI]: 0.41 [0.18-0.91], P = 0.029) and albumin (HR [95% CI]: 0.12 [0.02-0.88], P = 0.038) levels as independent factors for poorer OS. Patient with both decreased hemoglobin and albumin levels had the worst OS (P = 0.001) and DFS (P = 0.001) than other risk groups. Subgroup analyses proved decreased hemoglobin and albumin levels predicted poorer OS independent of cancer types.ConclusionsPreoperative hemoglobin and albumin levels may serve as prognostic predictors after adrenal metastasectomy. A prognostic model that combines hemoglobin and albumin can improve accuracy in predicting patient outcomes and be easily implemented in clinical practice.
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页数：11
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