Carotenoids as modulators of the PI3K/Akt/mTOR pathway: innovative strategies in cancer therapy

被引：1

作者：

Utpal, Biswajit Kumar ^{[1
]}

Dehbia, Zerrouki ^{[2
]}

Zidan, B. M. Redwan Matin ^{[3
]}

Sweilam, Sherouk Hussein ^{[4
,5
]}

Singh, Laliteshwar Pratap ^{[6
]}

Arunkumar, M. S. ^{[7
]}

Sona, M. ^{[7
]}

Panigrahy, Uttam Prasad ^{[8
]}

Keerthana, R. ^{[7
]}

Mandadi, Sandhya Rani ^{[9
]}

Rab, Safia Obaidur ^{[10
]}

Alshehri, Mohammed Ali ^{[11
]}

Koula, Doukani ^{[2
,12
]}

Suliman, Muath ^{[10
]}

Nafady, Mohamed H. ^{[13
]}

Emran, Talha Bin ^{[1
]}

机构：

[1] Daffodil Int Univ, Fac Hlth & Life Sci, Dept Pharm, Dhaka 1207, Bangladesh

[2] Univ Ibn Khaldoun, Fac Nat & Life Sci, Lab AgroBiotechnol & Nutr Semi Arid Zones, Tiaret, Algeria

[3] Univ Dhaka, Fac Pharm, Dept Pharm, Dhaka 1000, Bangladesh

[4] Prince Sattam Bin Abdulaziz Univ, Dept Pharmacognosy, Coll Pharm, Al Kharj 11942, Saudi Arabia

[5] Egyptian Russian Univ, Fac Pharm, Dept Pharmacognosy, Suez Rd, Badr City 11829, Cairo, Egypt

[6] Gopal Narayan Singh Univ, Narayan Inst Pharm, Dept Pharmaceut Chem, Jamuhar, Bihar, India

[7] Karpagam Acad Higher Educ, Fac Pharm, Coimbatore 641021, Tamil Nadu, India

[8] Assam Town Univ, Fac Pharmaceut Sci, Sankar Madhab Path Gandhi Nagar, Gauhati 781026, Assam, India

[9] Vishnu Inst Pharmaceut Educ & Res, Dept Pharmaceut, Tuljaraopet 502313, Telangana, India

[10] King Khalid Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Abha, Saudi Arabia

[11] Univ Tabuk, Fac Sci, Dept Biol, Tabuk 71491, Saudi Arabia

[12] Univ Abdelhamid Ibn Badis, Lab Anim Prod Sci & Tech, Mostaganem, Algeria

[13] Misr Univ Sci & Technol, Fac Appl Hlth Sci Technol, Giza, Egypt

来源：

MEDICAL ONCOLOGY | 2024年 / 42卷 / 01期

关键词：

Carotenoids; Cancers; PI3K/Akt/mTOR pathway; Cell survival; Metastasis; GROWTH-FACTOR RECEPTOR; CELL NUCLEAR ANTIGEN; TRANS-RETINOIC ACID; NF-KAPPA-B; BREAST-CANCER; BETA-CAROTENE; SIGNALING PATHWAY; GASTRIC-CANCER; LUNG-CANCER; IN-VIVO;

D O I：

10.1007/s12032-024-02551-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer progression is primarily driven by the uncontrolled activation of cellular signaling pathways, with the PI3K/Akt/mTOR (PAMT) pathway playing a central role. This pathway significantly contributes to the proliferation and survival of cancer cells, and its hyperactivity is a major challenge in managing several types of malignancies. This article delves into the promising potential of carotenoids, natural pigments found in abundance in fruits and vegetables, as a novel therapeutic strategy for cancer treatment. By specifically targeting and inhibiting the PAMT pathway, carotenoids may effectively disrupt the growth and survival of cancer cells. The article examines the complex mechanisms underlying these interactions and highlights the obstacles faced in cancer treatment. It proposes a compelling approach to developing therapies that leverage natural products to target this critical pathway, offering a fresh perspective on cancer treatment. Further research is essential to enhance the therapeutic efficacy of these compounds.

引用

页数：25

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