Luminescent Nanozyme-Based Sensors for Bacteria Detection

被引:0
作者
Chumakov, D. S. [1 ]
Evstigneeva, S. S. [1 ]
Guliy, O. I. [1 ]
机构
[1] Russian Acad Sci IBPPM RAS, Inst Biochem & Physiol Plants & Microorganisms, Subdiv Fed State Budgetary Res Inst, Saratov Fed Sci Ctr, Saratov 410049, Russia
基金
俄罗斯科学基金会;
关键词
nanozymes; luminescence; detection; bacteria; bacterial biofilms; OXIDASE-LIKE ACTIVITY; FLUORESCENCE DETECTION; HYDROGEN-PEROXIDE; ANTIBACTERIAL; GLUTATHIONE; ROBUST; ASSAY; IONS;
D O I
10.1134/S0003683824606139
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Bacterial infections still remain one of the main problems for healthcare, due to difficulties in timely diagnosis and increasing microbial resistance. Based on advanced nanotechnologies, in particular, nanozymes, as artificial enzymes with a wide spectrum of action, it is possible to create completely new tools for detecting infectious agents. Recent advances in the development of luminescent nanozymes capable of identifying pathogenic bacteria are discussed. The basic information about nanozymes with luminescent properties and their advantages over other variants of nanozymes are considered, and the key mechanisms for generating a luminescent signal that make it possible to detect bacterial cells are revealed. The main focus of the review is on the comprehensive characterization of luminescent sensor systems developed to date, which are aimed at visualizing bacteria, both in a free-living form and in biofilm formation. In addition, a description is given of nanozyme-based sensors that selectively detect biomarkers of bacterial infections using a luminescent signal. This review is focused on further progress in the development of luminescent nanozymes for the detection of bacterial pathogens, as well as on the search for innovative nanozyme technologies that expand the capabilities of clinical microbiology.
引用
收藏
页码:1022 / 1034
页数:13
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