Prognostic value of Glasgow prognostic score in hematological malignancies: a systematic review and meta-analysis

被引：0
作者：
Jiang, Lijun [1 ]
Jin, Wenting [1 ]
机构：
[1] Jiaxing Univ, Dept Hematol, Affiliated Hosp, 1882 Zhonghuan South Rd, Jiaxing 314000, Zhejiang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2025年 / 121卷 / 04期
关键词：
Lymphoma; Leukemia; Myeloma; Prognosis; Inflammation; B-CELL LYMPHOMA; SERUM LACTATE-DEHYDROGENASE; INFLAMMATORY MARKERS; SIGNIFICANT PREDICTOR; R-CHOP; CANCER; SURVIVAL; DIAGNOSIS; GPS;
D O I：
10.1007/s12185-025-03935-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
ObjectiveThe Glasgow prognostic score (GPS) is used to predict the prognosis of several cancers. This first systematic review and meta-analysis evaluated the role of GPS in predicting overall survival (OS) and progression-free survival (PFS) in patients with hematological malignancies.MethodsEmbase, PubMed, CENTRAL, Scopus, and Google Scholar were screened for studies evaluating the prognostic role of GPS in hematological malignancies.ResultsTwelve studies were eligible. Meta-analysis showed that patients with GPS of >= 1 and >= 2 had worse OS than those with GPS of 0. We noted that both GPS scores of >= 1 and >= 2 were associated with significantly poor PFS in patients with hematological malignancies. Results remained robust on sensitivity analysis.ConclusionGPS can be used as a predictor of OS and PFS in patients with hematological malignancies. High GPS scores can lead to a twofold higher risk of poor OS and PFS.
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收藏
页码：450 / 461
页数：12
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