3D printed porous magnesium metal scaffolds with bioactive coating for bone defect repair: enhancing angiogenesis and osteogenesis

被引：3

作者：

Ye, Jianting ^{[1
]}

Miao, Bozun ^{[2
,3
]}

Xiong, Yingjie ^{[1
]}

Guan, Yanjun ^{[1
]}

Lu, Yuzheng ^{[1
,4
]}

Jia, Zhibo ^{[1
,5
]}

Wu, Yanbin ^{[1
]}

Sun, Xiaohan ^{[1
]}

Guan, Congcong ^{[1
,6
]}

He, Ruichao ^{[1
,6
]}

Xiong, Xing ^{[1
]}

Jia, Huihui ^{[1
]}

Jiang, Hongyu ^{[1
]}

Liu, Zexian ^{[1
]}

Zhang, Yuxuan ^{[1
,7
]}

Wei, Yu ^{[1
]}

Lin, Wancheng ^{[1
,4
]}

Wang, Aiyuan ^{[1
]}

Wang, Yu ^{[1
]}

Meng, Haoye ^{[1
]}

Xu, Wenjing ^{[1
]}

Yuan, Guangyin ^{[2
,3
]}

Peng, Jiang ^{[1
]}

机构：

[1] Fourth Med Ctr Chinese PLA Gen Hosp, Inst Orthoped, Key Lab Musculoskeletal Trauma & War Injuries PLA, Beijing Key Lab Regenerat Med Orthoped, 51 Fucheng Rd, Beijing 100048, Peoples R China

[2] Shanghai Jiao Tong Univ, Natl Engn Res Ctr Light Alloy Net Forming, Shanghai 200240, Peoples R China

[3] Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composite, Sch Mat Sci & Engn, Shanghai 200240, Peoples R China

[4] Capital Med Univ, Beijing Shijitan Hosp, Dept Spine Surg, 10 Tieyi Rd, Beijing 100038, Peoples R China

[5] Hebei North Univ, Zhangjiakou 075051, Peoples R China

[6] Nankai Univ, Sch Med, Tianjin 300071, Peoples R China

[7] Shanxi Prov Peoples Hosp, Taiyuan 030012, Shanxi, Peoples R China

来源：

JOURNAL OF NANOBIOTECHNOLOGY | 2025年 / 23卷 / 01期

关键词：

3D printing; Biodegradable magnesium alloy; Nanocomposite coating; Neovascularization; Bone regeneration; IN-VITRO; DIFFERENTIATION; ALLOY;

D O I：

10.1186/s12951-025-03222-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In orthopedics, the effective treatment of bone defects remains a major challenge. Magnesium (Mg) metals, with their excellent biocompatibility and favorable osteoconductivity, osteoinductivity, and osseointegration properties, hold great promise for addressing this issue. However, the rapid degradation rate of magnesium restricts its clinical application. In this study, a triply periodic minimal surface (TPMS)-structured porous magnesium alloy (Mg-Nd-Zn-Zr, JDBM) was fabricated using the laser powder bed fusion (LPBF) process. Strontium-doped octacalcium phosphate (SrOCP) and strontium hydrogen phosphate biphasic composite coatings were applied to the surface of the scaffolds. The results showed that the TPMS structure exhibited porous biomimetic characteristics that resemble cancellous bone, promoting vascular ingrowth and new bone formation. Additionally, the SrOCP coating significantly increased the surface roughness and hydrophilicity of the scaffold, which enhanced cell adhesion and osteogenic differentiation. The SrOCP coating also markedly reduced the degradation rate of the JDBM scaffolds while ensuring the sustained release of bioactive ions (Mg2+, Zn2+, Sr2+, and Ca2+), thus maintaining the scaffolds' biofunctional activity. Compared to JDBM scaffolds, JDBM/SrOCP scaffolds exhibited better biocompatibility and stronger vascularization and bone regeneration capabilities both in vitro and in vivo. Overall, this study presents a novel strategy for the repair of bone defects using magnesium-based biomaterials, providing new insights for future clinical applications.

引用

页数：25