Wogonin suppresses proliferation, invasion and migration in gastric cancer cells via targeting the JAK-STAT3 pathway

被引：0

作者：

Song, Yang ^{[1
]}

Zhao, Hui ^{[3
]}

Yu, Runze ^{[5
]}

Zhang, Yang ^{[4
]}

Zou, Yongxin ^{[5
]}

Liu, Xiaofei ^{[6
]}

Sun, Shuna ^{[2
]}

机构：

[1] Qilu Univ Technol, Shandong Acad Sci, Sch Bioengn, Jinan 250353, Peoples R China

[2] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Shandong Prov Hosp Tradit Chinese Med, Clin Med Coll 1,Dept Dermatol, Jinan 250011, Peoples R China

[3] Shandong Univ, Adv Med Res Inst, Jinan 250012, Peoples R China

[4] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Pulm & Critial Care Med, Jinan 250011, Peoples R China

[5] Shandong Univ, Sch Basic Med Sci, Dept Med Genet, Key Lab Expt Teratol,Minist Educ, Jinan 250012, Peoples R China

[6] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Breast & Thyroid Surg, Jinan 250011, Peoples R China

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

关键词：

Wogonin; Gastric cancer; Natural compounds; STAT3 signaling pathways; Antitumor; APOPTOSIS; STAT3; ACTIVATION; RESISTANCE;

D O I：

10.1038/s41598-024-81196-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wogonin is a compound extracted from the medicinal plant Scutellaria baicalensis Geogi and has been found to exert antitumor activities in a variety of malignancies. However, the molecular mechanisms involved in the anti-gastric cancer (GC) effects of wogonin remain poorly understood. In the present study, we found that wogonin treatment inhibited the proliferation of GC cells, induced apoptosis and G0/G1 cell arrest, and suppressed the migration and invasion of SGC-7901 and BGC-823 cells in vitro. In addition, wogonin inhibited in vivo tumor growth in SGC-7901 xenograft mice. Transcriptomic analysis suggested that wogonin affected several signaling pathways closely related to tumor proliferation and metastasis, including the STAT3 signaling pathway. Further research indicated that wogonin may exert antitumor effects in GC cells by downregulating the JAK-STAT3 pathway. Altogether, our results demonstrate that wogonin exerts antitumor effects by perturbing JAK-STAT3 signaling in GC cells and that wogonin may be a potential therapeutic option for GC.

引用

页数：15

共 66 条

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