Latent mechanisms of language disorganization relate to specific dimensions of psychopathology

被引:1
作者
Fradkin, Isaac [1 ,2 ]
Adams, Rick A. [1 ,3 ]
Siegelman, Noam [2 ,4 ]
Moran, Rani [1 ,5 ]
Dolan, Raymond J. [1 ,6 ]
机构
[1] Max Planck Univ Coll London, Ctr Computat Psychiat & Ageing Res, London, England
[2] Hebrew Univ Jerusalem, Dept Psychol, Jerusalem, Israel
[3] UCL, Ctr Med Image Comp & AI, London, England
[4] Hebrew Univ Jerusalem, Dept Cognit & Brain Sci, Jerusalem, Israel
[5] Queen Mary Univ London, Sch Biol & Behav Sci, London, England
[6] UCL, Wellcome Trust Ctr Human Neuroimaging, London, England
来源
NATURE MENTAL HEALTH | 2024年 / 2卷 / 12期
基金
英国惠康基金; 英国工程与自然科学研究理事会; 欧盟地平线“2020”;
关键词
FORMAL THOUGHT-DISORDER; SCHIZOTYPAL TRAITS; SCHIZOPHRENIA; SCALES; MAGNETOENCEPHALOGRAPHY; VALIDATION; PSYCHOSIS; ANXIETY; CONTEXT; VERSION;
D O I
10.1038/s44220-024-00351-w
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Comprehensible communication is critical for social functioning and well-being. In psychopathology, incoherent discourse is assumed to reflect disorganized thinking, which is classically linked to psychotic disorders. However, people do not express everything that comes to mind, rendering inferences from discourse to the underlying structure of thought challenging. Indeed, a range of psychopathologies are linked to self-reported disorganized thinking in the absence of language output incoherence. Here we combine natural language processing and computational modeling of free association to detail the relationship between disorganized thinking and language (in)coherence in a large sample of participants varying across different dimensions of psychopathology. Our approach allowed us to differentiate between disorganized thinking, disinhibited thought expression and deliberate creativity. We find evidence for both under-regulated and over-regulated disorganized thinking, which relate to two specific dimensions of psychopathology: self-reported eccentricity and suspiciousness. Broadly, these results underscore the theoretical progress afforded by analyzing latent dimensions underlying behavior and psychopathology.
引用
收藏
页码:1486 / 1497
页数:19
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