Serine metabolism in aging and age-related diseases

被引：0
|
作者：
Shan, Shengshuai [1 ]
Hoffman, Jessica M. [1 ]
机构：
[1] Augusta Univ, Dept Biol Sci, Augusta, GA 30912 USA
来源：
GEROSCIENCE | 2025年 / 47卷 / 01期
关键词：
Serine; Aging; Age-related diseases; Longevity; Oxidative stress; Metabolism; ONE-CARBON METABOLISM; LIFE-SPAN EXTENSION; AMYOTROPHIC-LATERAL-SCLEROSIS; INDUCED OXIDATIVE STRESS; AMINO-ACIDS; FATTY LIVER; METHIONINE METABOLISM; DIETARY RESTRICTION; GLYCINE METABOLISM; MOUSE MODEL;
D O I：
10.1007/s11357-024-01444-1
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Non-essential amino acids are often overlooked in biomedical research; however, they are crucial components of organismal metabolism. One such metabolite that is integral to physiological function is serine. Serine acts as a pivotal link connecting glycolysis with one-carbon and lipid metabolism, as well as with pyruvate and glutathione syntheses. Interestingly, increasing evidence suggests that serine metabolism may impact the aging process, and supplementation with serine may confer benefits in safeguarding against aging and age-related disorders. This review synthesizes recent insights into the regulation of serine metabolism during aging and its potential to promote healthy lifespan and mitigate a spectrum of age-related diseases.
引用
收藏
页码：611 / 630
页数：20
相关论文
共 50 条
  • [21] Astrocyte activation and altered metabolism in normal aging, age-related CNS diseases, and HAND
    Cotto, Bianca
    Natarajaseenivasan, Kalimuthusamy
    Langford, Dianne
    JOURNAL OF NEUROVIROLOGY, 2019, 25 (05) : 722 - 733
  • [22] Astrocyte activation and altered metabolism in normal aging, age-related CNS diseases, and HAND
    Bianca Cotto
    Kalimuthusamy Natarajaseenivasan
    Dianne Langford
    Journal of NeuroVirology, 2019, 25 : 722 - 733
  • [23] Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases
    Chondrogianni, Niki
    Voutetakis, Konstantinos
    Kapetanou, Marianna
    Delitsikou, Vasiliki
    Papaevgeniou, Nikoletta
    Sakellari, Marianthi
    Lefaki, Maria
    Filippopoulou, Konstantina
    Gonos, Efstathios S.
    AGEING RESEARCH REVIEWS, 2015, 23 : 37 - 55
  • [24] Nutrigenomics as a tool to study the impact of diet on aging and age-related diseases: the Drosophila approach
    Evangelakou, Zoi
    Manola, Maria
    Gumeni, Sentiljana
    Trougakos, Ioannis P.
    GENES AND NUTRITION, 2019, 14 (1)
  • [25] Aging, frailty and age-related diseases
    T. Fulop
    A. Larbi
    J. M. Witkowski
    J. McElhaney
    M. Loeb
    A. Mitnitski
    G. Pawelec
    Biogerontology, 2010, 11 : 547 - 563
  • [26] Epigenetics in aging and age-related diseases
    Santa-Cruz Calvo, Sara
    Navas, Placido
    Lopez-Lluch, Guillermo
    APPROACHES TO AGING CONTROL, 2010, (14): : 68 - 74
  • [27] Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review
    Anik, Muzahidul I.
    Mahmud, Niaz
    Al Masud, Abdullah
    Khan, Md Ishak
    Islam, Md Nurul
    Uddin, Shihab
    Hossain, M. Khalid
    ACS APPLIED BIO MATERIALS, 2022, 5 (09) : 4028 - 4054
  • [28] Molecular Inflammation as an Underlying Mechanism of the Aging Process and Age-related Diseases
    Chung, H. Y.
    Lee, E. K.
    Choi, Y. J.
    Kim, J. M.
    Kim, D. H.
    Zou, Y.
    Kim, C. H.
    Lee, J.
    Kim, H. S.
    Kim, N. D.
    Jung, J. H.
    Yu, B. P.
    JOURNAL OF DENTAL RESEARCH, 2011, 90 (07) : 830 - 840
  • [29] Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases
    Belser, Misa
    Walker, David W.
    FRONTIERS IN GENETICS, 2021, 12
  • [30] The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates
    Franceschi, Claudio
    Garagnani, Paolo
    Morsiani, Cristina
    Conte, Maria
    Santoro, Aurelia
    Grignolio, Andrea
    Monti, Daniela
    Capri, Miriam
    Salvioli, Stefano
    FRONTIERS IN MEDICINE, 2018, 5
12345