18F-FDG PET/CT metabolic parameter changes to assess vascular inflammatory response in patients with diffuse large B-cell lymphoma

被引：0
作者：
Xie, Wenli [1 ]
Cao, Lixiu [2 ,3 ]
Yu, Jing [4 ]
Tian, Aijuan [4 ]
Wang, Jin [5 ,7 ]
Lin, Runlong [4 ,6 ]
机构：
[1] Dalian Med Univ, Hosp 2, Dept Cardiovasc Med, Dalian, Peoples R China
[2] Hebei Key Lab Mol Oncol, Tangshan, Peoples R China
[3] Tangshan Peoples Hosp, Dept Emiss Comp Tomog, Tangshan, Peoples R China
[4] Dalian Med Univ, Hosp 2, Dept Nucl Med, Dalian, Peoples R China
[5] Dalian Med Univ, Hosp 2, Dept Vasc Surg, Dalian, Peoples R China
[6] Dalian Med Univ, Hosp 2, Dept Nucl Med, 467 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China
[7] Dalian Med Univ, Hosp 2, Dept Vasc Surg, 467 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China
来源：
BMC MEDICAL IMAGING | 2025年 / 25卷 / 01期
关键词：
Diffuse large B-cell lymphoma; Tumor-associated vascular toxicity; Vascular inflammation; F-18-FDG PET/CT; FDG-PET/CT; EANM; TOMOGRAPHY; GUIDELINES; FEATURES; SOCIETY; RISK;
D O I：
10.1186/s12880-025-01617-0
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Objective To study the changes in positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose integrated with computed tomography (F-18-FDG PET/CT) aortic target-to-background ratio (TBR) and aortic calcification scores before and after 6 cycles of chemotherapy with the rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen in patients with diffuse large B-cell lymphoma (DLBCL). Patients and methods We selected 161 patients with DLBCL who received 6 cycles of R-CHOP standard chemotherapy and underwent baseline and 6-cycle efficacy evaluations using F-18-FDG PET/CT examinations at the Second Hospital of Dalian Medical University from July 2017 to June 2023. Additionally, 125 patients who underwent F-18-FDG PET/CT for physical examination during the same period, without active malignancy or systemic inflammatory disease, were chosen as the control group. We measured metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of systemic lymphoma lesions in tumor patients. Aortic wall FDG uptake was semi quantitatively analyzed as TBR (target-to-blood pool ratio) in five different vascular regions using oncological F-18-FDG PET/CT. The aortic TBR difference (Delta TBR) was the difference between the post- and pre-chemotherapy TBR values. The degree of arterial segmental wall calcification was assessed using the CT semiquantitative method. Results Comparison of the pre-treatment group of DLBCL with the control group showed that aortic TBR (1.28 +/- 0.17 vs. 1.22 +/- 0.18, P < 0.05) were higher in the former group. Additionally, comparing different stage groups of patients with DLBCL revealed that aortic TBR (1.30 +/- 0.18 vs. 1.22 +/- 0.15, P < 0.05) were higher in the Stage III/IV group compared to the Stage I/II group. Aortic TBR was positively correlated with TLG (P = 0.016, R = 0.19) and MTV (P = 0.032, R = 0.17). Analysis of changes in aortic F-18-FDG uptake in patients with DLBCL after 6 cycles of treatment revealed that aortic TBR levels were significantly higher post-treatment compared to pre-treatment(P < 0.05). The aortic Delta TBR value was significantly higher in the progression group than in the complete remission group(P < 0.05). Conclusion Aortic wall F-18-FDG uptake is related to disease severity and prognosis, indicating a possible vascular effect of lymphoma and its therapeutic interventions. This work highlights an additional potential role of PET/CT in imaging oncology for evaluating disease severity and its consequences on the vasculature.
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页数：10
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共 35 条
[1]  
Karlstaedt A., Moslehi J., de Boer R.A., Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer, Nat Rev Cardiol, 19, 6, pp. 414-425, (2022)
[2]  
Clayton Z.S., Hutton D.A., Mahoney S.A., Seals D.R., Anthracycline chemotherapy-mediated vascular dysfunction as a model of accelerated vascular aging, Aging Cancer, 2, 1-2, pp. 45-69, (2021)
[3]  
Herrmann J., Lenihan D., Armenian S., Barac A., Blaes A., Cardinale D., Carver J., Dent S., Ky B., Lyon A.R., Et al., Defining cardiovascular toxicities of cancer therapies: an international Cardio-Oncology society (IC-OS) consensus statement, Eur Heart J, 43, 4, pp. 280-299, (2022)
[4]  
Campia U., Vascular effects of cancer treatments, Vasc Med, 25, 3, pp. 226-234, (2020)
[5]  
Patil S., Kata R., Teichner E., Subtirelu R., Ghonim M., Ghonim M., Al-Daoud O., Ismoilov M., Herpin L., Ayubcha C., Et al., Associations of subclinical microcalcification and inflammation with carotid atheroma development: a dual-tracer PET/CT study, Eur J Nucl Med Mol Imaging, (2025)
[6]  
Figueroa A.L., Subramanian S.S., Cury R.C., Et al., Distribution of inflammation within carotid atherosclerotic plaques with high-risk morphological features: a comparison between positron emission tomography activity, plaque morphology, and histopathology, Circ Cardiovasc Imaging, 5, 1, pp. 69-77, (2012)
[7]  
Kubota R., Yamada S., Kubota K., Ishiwata K., Tamahashi N., Ido T., Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography, J Nucl Med, 33, 11, pp. 1972-1980, (1992)
[8]  
Hecht H.S., Cronin P., Blaha M.J., Et al., 2016 SCCT/STR guidelines for coronary artery calcium scoring of Noncontrast noncardiac chest CT scans: A report of the society of cardiovascular computed tomography and society of thoracic radiology, J Thorac Imaging, 32, 5, pp. W54-W66, (2017)
[9]  
Shen H., Lian Y., Yin J., Et al., Cardiovascular risk stratification by automatic coronary artery calcium scoring on pretreatment chest computed tomography in diffuse large B-Cell lymphoma receiving Anthracycline-Based chemotherapy: A multicenter study, Circ Cardiovasc Imaging, 16, 2, (2023)
[10]  
de Boysson H., Dumont A., Liozon E., Et al., Giant-cell arteritis: concordance study between aortic CT angiography and FDG-PET/CT in detection of large-vessel involvement, Eur J Nucl Med Mol Imaging, 44, 13, pp. 2274-2279, (2017)
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