Family history of dementia and brain health in childhood and middle age: a prospective community-based study

被引：0

作者：

Hussainali, Rowina F. ^{[1
,2
,3
]}

Schuurmans, Isabel K. ^{[1
,2
,4
]}

Zijlmans, Jende L. ^{[1
]}

Cecil, Charlotte A. M. ^{[1
,4
,5
]}

Vernooij, Meike W. ^{[1
,6
,7
]}

Luik, Annemarie I. ^{[1
,4
]}

Muetzel, Ryan L. ^{[4
,6
,7
]}

Ikram, M. Arfan ^{[1
]}

Wolters, Frank J. ^{[1
,6
,7
]}

机构：

[1] Erasmus MC Univ Med Ctr Rotterdam, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus MC Univ Med Ctr Rotterdam, Generat R Study Grp, Rotterdam, Netherlands

[3] Erasmus MC Univ Med Ctr Rotterdam, Dept Obstet & Gynecol, Rotterdam, Netherlands

[4] Erasmus MC Univ Med Ctr Rotterdam, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands

[5] Leiden Univ, Med Ctr, Dept Biomed Data Sci Mol Epidemiol, Leiden, Netherlands

[6] Erasmus MC Univ Med Ctr Rotterdam, Dept Radiol & Nucl Med, Rotterdam, Netherlands

[7] Erasmus MC Univ Med Ctr Rotterdam, Alzheimer Ctr Erasmus MC, Rotterdam, Netherlands

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2024年 / 39卷 / 10期

关键词：

Family history; Dementia; Childhood; Midlife; Brain health; SMALL VESSEL DISEASE; ALZHEIMERS-DISEASE; NORMATIVE DATA; GENERATION R; MATERNAL HISTORY; APOE GENOTYPE; NORMAL ADULTS; HIGH-RISK; APOE-EPSILON-4; INDIVIDUALS;

D O I：

10.1007/s10654-024-01160-2

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We aimed to determine the association of family history of dementia with structural brain measures and cognitive performance in childhood and mid-life adulthood. We studied 1,259 parents (mean age: 47.3 years, range 31.9-67.4) and 866 of their children (mean age [range] at brain MRI: 9.9 years [8.8-11.9], and for cognition: 13.5 years [12.6-15.8]) of the population-based Generation R Study. Parents filled in a questionnaire on family history, and both parents and children underwent cognitive assessment and neuroimaging. Of all participants, 109 parents (8.6%) reported a parental family history of dementia and 73 children (8.4%) had a grandparental history of dementia with mean age of dementia diagnosis in those affected 75 years (+/- 7.3). We observed no associations of dementia family history with cognitive ability in either parents or their children, except for worse Purdue pegboard in parents with a parental history of dementia, compared to those without (mean difference [95%CI]: -1.23 [-2.15; -0.31], test range: 21-52). In parents and children, neuroimaging measures did not differ significantly by family history. Results did not depend on age, sex, and APOE genotype. Family history of dementia was associated with worse manual dexterity in mid-life adulthood, but not with any other measures of cognitive ability or subclinical brain health in childhood and mid-life. These findings suggest that the association of family history with dementia risk is due chiefly to neurodegenerative rather than neurodevelopmental processes, and might first present with reduced motor skills.

引用

页码：1151 / 1160

页数：10