Gut microbiota and Parkinson’s disease

被引：0

作者：

Wang Lin ^{[1
]}

Cui Ying ^{[1
]}

Han Bingyu ^{[1
]}

Du Yitong ^{[1
]}

Salewala Kenish Sirajbhai ^{[2
]}

Wang Shiya ^{[1
]}

Zhao Wenlu ^{[1
]}

Zhang Hongxin ^{[1
]}

Wang Sichen ^{[1
]}

Xu Xinran ^{[1
]}

Ma Jianpeng ^{[1
]}

Zhu Yan ^{[1
]}

Tuo Houzhen ^{[1
]}

机构：

[1] Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China

[2] International School, Capital Medical University, Beijing, China

来源：

中华医学杂志英文版 | 2025年 / 138卷 / 03期

关键词：

Parkinson’s disease; Microbiota-gut-brain axis; Gut microbiota; Neuroinflammation; Metabolism;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

1002 ;

摘要：

Emerging evidence suggests that dysbiosis of the gut microbiota is associated with the pathogenesis of Parkinson’s disease (PD), a prevalent neurodegenerative disorder. The microbiota-gut-brain axis plays a crucial role in the development and progression of PD, and numerous studies have demonstrated the potential therapeutic benefits of modulations in the intestinal microbiota. This review provides insights into the characterization of the gut microbiota in patients with PD and highlights associations with clinical symptoms and underlying mechanisms. The discussion underscores the increased influence of the gut microbiota in the pathogenesis of PD. While the relationship is not fully elucidated, existing research demonstrates a strong correlation between changes in the composition of gut microbiota and disease development, and further investigation is warranted to explain the specific underlying mechanisms.

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