CMTM6/PD-L1在肝细胞癌中的表达及研究新进展

被引：0

作者：

何锋

孔盼盼

李鸣一

阿里米热·塔依尔

机构：

[1] 新疆医科大学附属肿瘤医院肝胆胰外科一病区

来源：

现代消化及介入诊疗 | 2024年 / 29卷 / 11期

关键词：

趋化素样超家族6; 肝细胞癌; 程序性死亡受体配体1;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100214 ;

摘要：

CMTM6作为CKLF-like MARVEL跨膜结构域家族的重要成员，近年来在肿瘤研究中取得了显著进展。研究表明CMTM6能够与程序性死亡受体配体1(PD-L1)结合，稳定癌细胞表面PD-L1的表达，还能够正向调控免疫共刺激因子CD58的表达，影响肿瘤中细胞免疫反应。此外，CMTM6还可以促进肿瘤相关巨噬细胞M2极化以及稳定波形蛋白，影响肿瘤微环境，促进肿瘤细胞的免疫逃逸。在这篇综述中，我们将简要介绍一下CMTM6与PD-L1在肝细胞癌中的表达及其研究进展。

引用

页码：1357 / 1361

页数：5

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