Probing and imaging phospholipid dynamics in live cells

被引：0

作者：

Zhongsheng Wu ^{[1
,2
]}

Yongtao Du ^{[1
,2
]}

Tom Kirchhausen ^{[3
,4
,5
]}

Kangmin He ^{[1
,2
]}

机构：

[1] State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

[2] University of Chinese Academy of Sciences

[3] Department of Cell Biology, Harvard Medical School

[4] Program in Cellular and Molecular Medicine, Boston Children's Hospital

[5] Department of Pediatrics, Harvard Medical

来源：

Life Metabolism | 2024年 / 3卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R318 [生物医学工程]; TP212.3 [生物传感器、医学传感器];

学科分类号：

0831 ;

摘要：

Distinct phospholipid species display specific distribution patterns across cellular membranes, which are important for their structural and signaling roles and for preserving the integrity and functionality of the plasma membrane and organelles. Recent advancements in lipid biosensor technology and imaging modalities now allow for direct observation of phospholipid distribution, trafficking,and dynamics in living cells. These innovations have markedly advanced our understanding of phospholipid function and regulation at both cellular and subcellular levels. Herein, we summarize the latest developments in phospholipid biosensor design and application, emphasizing the contribution of cutting-edge imaging techniques to elucidating phospholipid dynamics and distribution with unparalleled spatiotemporal precision.

引用

页码：27 / 41

页数：15

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