Cucurbit[6]uril-stabilized copper oxide nanoparticles: Synthesis, potent antimicrobial and in vitro anticancer activity

被引：0

作者：

Rajeeve, Anakha D. ^{[1
,2
]}

Veetil, Vyshnavi T. ^{[1
,2
]}

Krishnan Namboori, P.K. ^{[3
,4
,5
,6
]}

Yamuna, R. ^{[1
,2
]}

Rajendran, Arivazhagan ^{[7
]}

机构：

[1] Department of Chemistry, Amrita School of Physical Sciences Coimbatore, Amrita Vishwa Vidyapeetham

[2] Bio-materials Chemistry Research Laboratory, Amrita School of Engineering Coimbatore, Amrita Vishwa Vidyapeetham

[3] Amrita School of Artificial Intelligences, Coimbatore Amrita Vishwa Vidyapeetham

[4] Computational Chemistry Group (CCG), Amrita School of Engineering, Coimbatore, Amrita Vishwa Vidyapeetham

[5] Center for Computational Engineering and Networking (CEN), Amrita School of Engineering, Coimbatore, Amrita Vishwa Vidyapeetham

[6] Biopharma Solutions, Coimbatore

[7] Institute of Advanced Energy, Kyoto University, Gokasho, Uji, Kyoto

来源：

Journal of Molecular Liquids | 2024年 / 415卷

关键词：

Antimicrobial; Antioxidant; Copper oxide; Cucurbit[6]uril; Cytotoxicity; Lung cancer;

D O I：

10.1016/j.molliq.2024.126323

中图分类号：

学科分类号：

摘要：

The use of copper oxide nanoparticles (NPs) in cancer treatment and diagnosis is a rapidly growing area of nanotechnology. Here, we synthesized cucurbit[6]uril (CB6)-stabilized Cu2O (Cu2O–CB6) and CuO (CuO–CB6) NPs via a simple reduction method. Their formation and physicochemical characteristics were confirmed using various spectroscopic techniques. Electron microscopy images revealed spherical CuO and Cu2O NPs on CB6 surface, with average particle sizes of approximately 40 and 25 nm for Cu2O–CB6 and CuO–CB6, respectively. X-ray diffraction patterns confirmed cubic and monoclinic structures for Cu2O–CB6 and CuO–CB6, respectively. Subsequently, we evaluated the antibacterial and antifungal activities of both NPs. We then assessed their anticancer efficacy using A549 human lung cancer cells via dimethyl thiazolyl tetrazolium bromide (MTT) assay. CuO–CB6 demonstrated excellent concentration-dependent anti-proliferative effects with an IC50 value of 12.35 ± 0.05 µg/mL. Moreover, CuO–CB6 exhibited superior antibacterial, antifungal, antioxidant, and anticancer activities compared to the one reported for CuO NPs. Our in vitro MTT assays, antioxidant activity, and apoptosis studies suggest the potential of these NPs as anticancer agents. © 2024 Elsevier B.V.

引用

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