BLUsH for brain imaging

被引：0
作者：
Liu, Yuxia [1 ,2 ]
Sui, Mingyu [1 ,2 ,3 ,4 ]
Liu, Xiaogang [1 ,2 ,3 ,4 ]
机构：
[1] Natl Univ Singapore, Dept Chem, 3 Sci Dr 3, Singapore 117543, Singapore
[2] Natl Univ Singapore, Inst Hlth N1, 28 Med Dr, Singapore 117456, Singapore
[3] Joint Sch Natl Univ Singapore, Binhai 350207, Fuzhou, Peoples R China
[4] Tianjin Univ, Int Campus, Binhai 350207, Fuzhou, Peoples R China
来源：
MATTER | 2024年 / 7卷 / 09期
关键词：
BIOLUMINESCENCE;
D O I：
10.1016/j.matt.2024.07.008
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Bioluminescent reporters are widely used in fundamental and preclinical biological research. However, light absorption and scatsources in deep locations, such as the brain, where the skull significantly blocks optical signal transmission. This preview highlights an ingenious approach that employs a cellular near-field camera to convert optical signals into hemodynamic changes detectable by magnetic resonance imaging. This transformation overcomes the optical limitations of tissue penetration depth and enables more precise mapping of bioluminescence sources in the brain.
引用
收藏
页码：2798 / 2800
页数：3
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