Sjögren’s Syndrome: The Role of Serological Profiles Versus Minor Salivary Gland Histopathology

被引：0
作者：
Uddin, Shahad [1 ]
Holm, Håkon [1 ]
Rahel, Arian [1 ]
Skarstein, Kathrine [2 ]
Jensen, Janicke Liaaen [1 ]
Hynne, Håvard [1 ]
机构：
[1] Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo
[2] Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Bergen
来源：
Applied Sciences (Switzerland) | 2024年 / 14卷 / 24期
关键词：
anti-SSA; anti-SSB; focus score; serology; Sjögren’s syndrome;
D O I：
10.3390/app142411482
中图分类号：
学科分类号：
摘要：
Between the years 2008 and 2023, 306 patients were referred to the Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, for salivary gland biopsy after clinical suspicion of Sjögren’s syndrome. This study aimed to investigate possible associations between serology and minor salivary gland histopathology by stratifying patients according to serology features (negative, single, or double seropositivity according to anti-SSA and anti-SSB), focus score (FS, negative, or actual score), and germinal centers (GCs). Information was collected from referrals and visits. Collected information included oral and ocular dryness symptoms, sialometry, Schirmer I test, histopathological analysis, and serological findings. Patients were classified using the 2002 American European Consensus Group classification criteria and were stratified into seven subgroups according to their serological profiles and FS, which were compared. The majority of patients were females, and the most frequently referred age group was 50–59 years of age. Most patients had both oral and ocular symptoms. Seropositive patients had higher median FS compared to seronegative patients. Double-seropositive patients had significantly higher median FS compared to single-seropositive patients. The results indicated that anti-SSB together with anti-SSA plays a role in disease severity in the salivary glands. In addition to anti-SSA, anti-SSB should be routinely evaluated as a possible predictor of the severity of inflammatory destruction in the salivary gland tissue. © 2024 by the authors.
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