Rational nanoparticle design for efficient biomolecule delivery in plant genetic engineering

被引：0

作者：

Zhao, Yue ^{[1
]}

Thenarianto, Calvin ^{[1
]}

Sevencan, Cansu ^{[1
]}

Rajappa, Sivamathini ^{[1
]}

Shen, Di ^{[1
]}

Puangpathumanond, Suppanat ^{[1
]}

Yao, Xiaomin ^{[1
]}

Lew, Tedrick Thomas Salim ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117585, Singapore

来源：

NANOSCALE | 2024年 / 16卷 / 46期

基金：

新加坡国家研究基金会;

关键词：

MESOPOROUS SILICA NANOPARTICLES; CELL-PENETRATING PEPTIDES; AGROBACTERIUM-MEDIATED TRANSFORMATION; INTRACELLULAR DELIVERY; FLORAL DIP; DNA; TRANSLOCATION; TRANSPORT; WATER; ACCUMULATION;

D O I：

10.1039/d4nr03760j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pressing issue of food security amid climate change necessitates innovative agricultural practices, including advanced plant genetic engineering techniques. Efficient delivery of biomolecules such as DNA, RNA, and proteins into plant cells is essential for targeted crop improvements, yet traditional methods face significant barriers. This review discusses the multifaceted challenges of biomolecule delivery into plant cells, emphasizing the limitations of conventional methods. We explore the promise of nanoparticle-mediated delivery systems as a versatile alternative. By highlighting the diverse design parameters used to tune the physical and chemical properties of nanoparticles, we analyze how these factors influence delivery efficacy. Furthermore, we summarize recent advancements in nanoparticle-mediated delivery, showcasing successful examples of DNA, RNA, and protein transport into plant cells. By understanding and optimizing these design parameters, we can enhance the potential of nanoparticle technologies in plant genetic engineering, paving the way for more resilient and productive agriculture.

引用

页码：21264 / 21278

页数：15

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