Real-Time and Ultrasensitive Prostate-Specific Antigen Sensing Using Love-Mode Surface Acoustic Wave Immunosensor Based on MoS2@Cu2O-Au Nanocomposites

被引：2

作者：

Yu, Yan ^{[1
]}

Xie, Haiyu ^{[1
]}

Zhou, Tao ^{[1
]}

Zhang, Haonan ^{[1
]}

Lu, Chenze ^{[2
]}

Tao, Ran ^{[1
]}

Tang, Zhaozhao ^{[3
]}

Luo, Jingting ^{[1
]}

机构：

[1] Shenzhen Univ, Coll Phys & Optoelect Engn, GuangDong Engn Technol Res Ctr Breath Test, Shenzhen Key Lab Adv Thin Films & Applicat, Shenzhen 518060, Peoples R China

[2] China Jiliang Univ, Coll Life Sci, Key Lab Specialty Agriprod Qual & Hazard Controlli, Hangzhou 310018, Zhejiang, Peoples R China

[3] Shenzhen Univ, Coll Chem & Environm Engn, Water Sci & Environm Engn Res Ctr, Shenzhen 518060, Peoples R China

来源：

SENSORS | 2024年 / 24卷 / 23期

基金：

中国国家自然科学基金;

关键词：

Love-mode surface acoustic wave (L-SAW); immunosensor; nanocomposite; prostate-specific antigen (PSA); real time; ultrasensitive; LABEL-FREE; CANCER; SENSOR;

D O I：

10.3390/s24237636

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Prostate-specific antigen (PSA) is a well-established tumour marker for prostatic carcinoma. In this study, we present a novel, real-time, and ultrasensitive Love-mode surface acoustic wave (L-SAW) immunosensor for PSA detection enhanced by MoS2@Cu2O-Au nanocomposite conjugation. The MoS2@Cu2O-Au nanocomposites were analyzed by SEM, XRD, and EDS. The experiments show a significant improvement in sensitivity and detection limit compared with the previous detection methods utilizing nanogold alone to detect PSA biomolecules. The experimental results show a good linear relationship when the range of PSA concentrations between 200 pg/mL and 5 ng/mL was tested. The experimental results also show good specificity against alpha 1 fetoprotein and L-tryptophan disruptors.

引用

页数：14

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