Temperature Measurement in Microwave-Induced Hyperthermia Treatments Using FBG Sensors

被引：0

作者：

Ospina-Mendivelso, Nicolas ^{[1
]}

Triana, Andres ^{[1
]}

Cano-Vasquez, Camilo ^{[1
,2
]}

Guarnizo, Hector F. ^{[2
]}

Fonseca-Benitez, A. V. ^{[3
]}

Perdomo, S. J. ^{[3
]}

Varon-Duran, Margarita ^{[1
]}

机构：

[1] Univ Nacl Colombia, High Frequency Elect & Telecommun Res Grp, Bogota 111321, Colombia

[2] Univ El Bosque, Hlth & Qual Life Res Grp, Fac Engn Electromagnetism, Bogota 110121, Colombia

[3] Univ El Bosque, Fac Dent, Cellular & Mol Immunol Res Grp, INMUBO, Bogota 110121, Colombia

来源：

JOURNAL OF LIGHTWAVE TECHNOLOGY | 2024年 / 42卷 / 18期

关键词：

Cell culture plate; cancer cellular spheroids; FBG sensors; hyperthermia; microwave hyperthermia treatment; temperature measurement; ABLATION; TISSUE;

D O I：

10.1109/JLT.2024.3442571

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

This paper presents a temperature study of cellular spheroids of the line MCF-07 under a hyperthermia (HT) treatment. A 3D printed culture plate embedded with optical fiber Bragg grating (FBG) sensors was designed to perform real-time temperature measurements of the spheroids. The proposed culture plate preserves the fiber sensors' integrity and functionality while remaining immune to the high electromagnetic interference scenario. A custom microwave applicator was designed to eliminate direct contact between the heating element and the samples, while considering the culture plate material's permittivity to ensure efficient heating. The heating setup maintains the samples' temperature within the HT range, which is crucial for predicting treatment outcomes. The sensors embedded in the designed culture plate achieved an accuracy within 0.31 degrees C. Initial observations of the temperature effects on spheroids are discussed, highlighting the potential of this approach to understand how temperature variations within the HT range affect cell cultures.

引用

页码：6451 / 6456

页数：6

共 23 条

[1] Mallory M., Gogineni E., Jones G.C., Greer L., Ii Simone C.B., Therapeutic hyperthermia: The old, the new, and the upcoming, Crit. Rev. oncol. / hematol., 97, pp. 56-64, (2016)
[2] Clavel C.M., Nowak-Sliwinska P., Puaunescu E., Dyson P.J., Thermoresponsive fluorinated small-molecule drugs: A new concept for efficient localized chemotherapy, MedChemComm, 6, 12, pp. 2054-2062, (2015)
[3] Sharma S.K., Shrivastava N., Rossi F., Tung L.D., Thanh N.T.K., Nanoparticles-based magnetic and photo induced hyperthermia for cancer treatment, Nano Today, 29, (2019)
[4] Vargas H.I., Et al., Focused microwave phased array thermotherapy for ablation of early-stage breast cancer results of thermal dose escalation, Ann. Surg. Oncol., 11, 2, pp. 139-146, (2004)
[5] Bruningk S.C., Ziegenhein P., Rivens I., Oelfke U., Haar G.T., A cellular automatonmodel for spheroid response to radiation and hyperthermia treatments, Sci. Rep., 9, 1, pp. 1-12, (2019)
[6] Roma-Rodrigues C., Pombo I., Fernandes A.R., Baptista P.V., Hyperthermia induced by gold nanoparticles and visible light photothermy combined with chemotherapy to tackle doxorubicin sensitive and resistant colorectal tumor 3D spheroids, Int. J. Mol. Sci., 21, 21, (2020)
[7] Nguyen P.T., Abbosh A., Crozier S., Microwave hyperthermia for breast cancer treatment using electromagnetic and thermal focusing tested on realistic breast models and antenna arrays, IEEE Trans. Antennas Propag., 63, 10, pp. 4426-4434, (2015)
[8] Li J., Wang X., Comparison of two small circularly polarized antennas for focused microwave hyperthermia, Proc. IEEE 13th Eur. Conf. Antennas Propag., pp. 1-4, (2019)
[9] Mendivelso N.O., Cano C.C., Coronel-Rico J., Guarnizo H.F., Duran M.V., Optical fiber bragg grating sensors for temperature measurements in the hyperthermia treatment, Proc. Latin Amer. Workshop Opt. Fiber Sensors, pp. 55-59, (2019)
[10] Mendivelso N.O., Cano C.C., Coronel-Rico J., Guarnizo H.F., Duran M.V., FBG sensors for temperature measurements in microwave irradiated breast phantoms, the Opt. Fiber Sensors Conf., (2020)

← 1 2 3 →