Split Gate Bulk-Planar Junctionless FET-Based Biosensor for Label-Free Detection of Biomolecules

被引:0
作者
Singh, Deepika [1 ,2 ]
Patil, Ganesh C. [1 ,2 ]
Choudhury, Bikash Dev [1 ,2 ]
机构
[1] Visvesvaraya Natl Inst Technol, Ctr VLSI & Nanotechnol, Nagpur 440010, Maharashtra, India
[2] Indian Inst Technol, Mumbai 400076, Maharashtra, India
关键词
Biomolecules; charge carrier density; Debye's length; sensitivity; split gate; FIELD-EFFECT TRANSISTOR; PH SENSITIVITY; RF LINEARITY; SILICON; PERFORMANCE;
D O I
10.1109/JSEN.2024.3439575
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
In this article, for the first time, we demonstrate the fabrication of low-cost split gate bulk planar junctionless field-effect transistor (SG-BPJLFET) for biosensing applications. In the fabrication process, the junctionless concept has been incorporated to reduce the thermal budget, random dopant fluctuations, and the fabrication complexities of the device. The measured transfer characteristics of the fabricated SG-BPJLFET show improved I-ON/I-OFF ratio of similar to 10(7) with the calculated mobility of 9.72 cm(2)/V center dot s and the charge carrier density of 1 x 10(18) cm(-3). For the fabricated device, Debye's length is found to be 6.45 nm, which can be used for the detection of protein complexes (such as streptavidin-biotin) by using 0.01 x phosphate buffer solution (PBS) in solution. The fabricated device is further simulated for the detection of biomolecules such as streptavidin and biotin. From the simulated results, it has been observed that the device has the capability to be used as a biosensor for detection of various protein complexes with higher sensitivity and selectivity.
引用
收藏
页码:28611 / 28618
页数:8
相关论文
共 40 条
[1]   Nanowire-templated microelectrodes for high-sensitivity pH detection [J].
Antohe, Vlad Andrei ;
Radu, Adrian ;
Matefi-Tempfli, Maria ;
Attout, Anne ;
Yunus, Sami ;
Bertrand, Patrick ;
Dutu, Constantin Augustin ;
Vlad, Alexandru ;
Melinte, Sorin ;
Matefi-Tempfli, Stefan ;
Piraux, Luc .
APPLIED PHYSICS LETTERS, 2009, 94 (07)
[2]   Signal-to-noise ratio measures efficacy of biological computing devices and circuits [J].
Beal, Jacob .
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2015, 3
[3]   Analysis of Partial Hybridization and Probe Positioning on Sensitivity of a Dielectric Modulated Junctionless Label Free Biosensor [J].
Bhattacharyya, Amit ;
Chanda, Manash ;
De, Debashis .
IEEE TRANSACTIONS ON NANOTECHNOLOGY, 2020, 19 :719-727
[4]   Ag-Loaded WS2-Based Pb2+ Ion Detection in Water [J].
Chaudhary, Sumit ;
Patel, Chandrabhan ;
Mahapatra, Brahamadutta ;
Kumar, Pawan ;
Dubey, Mayank ;
Sriram, Sharath ;
Mukherjee, Shaibal .
IEEE SENSORS JOURNAL, 2024, 24 (03) :2421-2428
[5]   Analytical Modeling of a Nanogap-Embedded FET for Application as a Biosensor [J].
Choi, Ji-Min ;
Han, Jin-Woo ;
Choi, Sung-Jin ;
Choi, Yang-Kyu .
IEEE TRANSACTIONS ON ELECTRON DEVICES, 2010, 57 (12) :3477-3484
[6]   Rapid thermal annealing treated spin-on doped antireflective radial junction Si nanopillar solar cell [J].
Choudhury, Bikash Dev ;
Anand, Srinivasan .
OPTICS EXPRESS, 2017, 25 (08) :A200-A207
[7]   Beyond the Debye length in high ionic strength solution: direct protein detection with field-effect transistors (FETs) in human serum [J].
Chu, Chia-Ho ;
Sarangadharan, Indu ;
Regmi, Abiral ;
Chen, Yen-Wen ;
Hsu, Chen-Pin ;
Chang, Wen-Hsin ;
Lee, Geng-Yen ;
Chyi, Jen-Inn ;
Chen, Chih-Chen ;
Shiesh, Shu-Chu ;
Lee, Gwo-Bin ;
Wang, Yu-Lin .
SCIENTIFIC REPORTS, 2017, 7
[8]   Noise considerations in field-effect biosensors [J].
Deen, M. J. ;
Shinwari, M. W. ;
Ranuarez, J. C. ;
Landheer, D. .
JOURNAL OF APPLIED PHYSICS, 2006, 100 (07)
[9]  
Duan XX, 2012, NAT NANOTECHNOL, V7, P401, DOI [10.1038/nnano.2012.82, 10.1038/NNANO.2012.82]
[10]   Crossing the Nernst Limit (59 mV/pH) of Sensitivity Through Tunneling Transistor-Based Biosensor [J].
Dwivedi, Praveen ;
Singh, Rohit ;
Chauhan, Yogesh Singh .
IEEE SENSORS JOURNAL, 2021, 21 (03) :3233-3240