Preparation and properties of reversible thermoresponsive hydrogels based on chitosan and silver ion

被引：0
作者：
Xu S. [1 ]
Zhang H. [1 ]
Qi P. [1 ]
Cao Z. [2 ]
Xing Y. [1 ]
机构：
[1] College of Chemistry and Chemical Engineering, Donghua University, Shanghai
[2] College of Biological Science and Medical Engineering, Donghua University, Shanghai
来源：
Jingxi Huagong/Fine Chemicals | 2024年 / 41卷 / 05期
关键词：
antibacterial performance; chitosan; functional materials; injectability; reversible thermoresponsive hydrogels; silver ion;
D O I：
10.13550/j.jxhg.20230491
中图分类号：
学科分类号：
摘要：
A series reversible thermoresponsive chitosan (CS)-Ag hydrogels were prepared from supermolecule complexation of CS with Ag+ of AgNO3, and characterized by FTIR, XRD, XPS, SEM and EDS for structure and chemical state analyses. The results showed that the CS-Ag hydrogels with the same gelation temperature could be obtained by adjusting the AgNO3 amount and pH simultaneously. CS-Ag-19 hydrogel, prepared under conditions of CS amount 0.60 g, AgNO3 amount 0.19 g, total volume 21 mL, and hydrogel pH 4.24, exhibited the best thermoreversible property, with cycle phase transformation for at least 5 times and stability for 5 months when stored at room temperature away from light. Moreover, the hydrogel displayed good antibacterial performance against Escherichia coli. The reversible thermoresponsiveness of CS-Ag hydrogel was controlled by supramolecular interactions among amino group at different temperatures. The equilibrium relationship between H+ and Ag+, driven by changes in temperature and concentration, and competitive reactions (protonation and complexation) against free amino groups made the hydrogel temperature sensitive and reversible. The injectability and thermo sensitivity of CS-Ag-19 made it promising as antibacterial dressing. © 2024 Fine Chemicals. All rights reserved.
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页码：1036 / 1042
页数：6
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