Unveiling Interactions between Self-Assembling Peptides and Neuronal Membranes

被引：0

作者：

Fontana, Federico ^{[1
,2
]}

Donato, Alice Cristina ^{[1
,3
]}

Malik, Ashish ^{[1
,2
]}

Gelain, Fabrizio ^{[1
,2
]}

机构：

[1] Center for Nanomedicine and Tissue Engineering (CNTE), A.S.S.T. Grande Ospedale Metropolitano Niguarda, Piazza dell’Ospedale Maggiore 3, Milan

[2] Fondazione IRCCS Casa Sollievo della Sofferenza, Unità di Ingegneria Tissutale, Viale Cappuccini 1, San Giovanni Rotondo, Foggia

[3] Histology Unit, Department of Molecular Medicine, University of Padova, Padova

来源：

Langmuir | 2024年 / 40卷 / 51期

关键词：

55;

D O I：

10.1021/acs.langmuir.4c02050

中图分类号：

学科分类号：

摘要：

The use of self-assembling peptide hydrogels in the treatment of spinal cord and brain injuries, especially when combined with adult neural stem cells, has shown great potential. To advance tissue engineering, it is essential to understand the effect of mechanochemical signaling on cellular differentiation. The elucidation of the molecular interactions at the level of the neuronal membrane still represents a promising area of investigation for many drug delivery and tissue engineering applications. An innovative molecular dynamics framework has been introduced to investigate the effect of SAP fibrils with different charges on neural membrane lipid domain dynamics. Such advance enables the in silico exploration of the biomimetic properties of SAP hydrogels and other polymeric biomaterials for tissue engineering applications. © 2024 The Authors. Published by American Chemical Society.

引用

页码：26811 / 26823

页数：12