Molecularly imprinted polymer sensors for biomarker detection in cardiovascular diseases

被引：2

作者：

Tang, Wenteng ^{[1
,2
]}

Han, Junlei ^{[1
,2
]}

Zhang, Wenhong ^{[1
,2
,3
]}

Li, Huimin ^{[1
,2
]}

Chen, Jun ^{[1
,2
]}

Song, Wei ^{[4
]}

Wang, Li ^{[1
,2
]}

机构：

[1] Qilu Univ Technol, Shandong Acad Sci, Sch Mech Engn, Jinan 250353, Peoples R China

[2] Shandong Inst Mech Design & Res, Jinan 250353, Peoples R China

[3] Donghua Univ, Coll Mech Engn, Shanghai 201620, Peoples R China

[4] Shandong First Med Univ, Shandong Prov Hosp, Dept Minimally Invas Comprehens Treatment Canc, Jinan 250021, Peoples R China

来源：

ANALYST | 2024年 / 149卷 / 23期

基金：

中国国家自然科学基金;

关键词：

GLASSY-CARBON ELECTRODE; LOW-DENSITY-LIPOPROTEIN; CARDIAC TROPONIN; ELECTROCHEMICAL DETECTION; DRUG ANALYSIS; MYOGLOBIN; MARKERS; NANOPARTICLES; NANOCOMPOSITE; BIOSENSOR;

D O I：

10.1039/d4an01103a

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Cardiovascular diseases (CVDs) are recognized as a significant threat to global health. The rapid, sensitive, and precise measurement of relevant biomarkers is essential for the timely diagnosis of CVDs. Molecularly imprinted polymers (MIPs), which act as artificial receptor recognition materials, have been extensively utilized in the detection of CVD biomarkers. Their widespread application is due to their cost-effectiveness, physical and chemical stability, straightforward preparation processes, and excellent compatibility with various sensor types. This review introduces the principles of MIP sensors in combination with electrochemical, optical, thermal transfer, and acoustic detection techniques for detecting CVD-related biomarkers. It then discusses methods developed over the past decade for detecting biomarkers of three major CVDs-coronary artery disease (CAD), acute myocardial infarction (AMI), and heart failure (HF)-using MIP sensors. Finally, the review summarizes the potential of MIP sensors in CVD biomarker detection and provides an outlook on future research directions.

引用

页码：5617 / 5637

页数：21

共 142 条

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