Platelet-derived biomaterials for targeted drug delivery and tissue repair

被引：0
作者：
Fang, Xinyu [1 ,2 ,3 ,4 ]
Li, Ya [1 ,2 ,3 ,4 ]
Wang, Yulin [1 ,2 ,3 ,4 ]
Cai, Rupeng [1 ]
Ao, Qiang [1 ,2 ,3 ,4 ]
机构：
[1] Sichuan Univ, Coll Biomed Engn, Natl Engn Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China
[2] Sichuan Univ, NMPA Key Lab Qual Res & Control Tissue Regenerat B, Chengdu 610064, Sichuan, Peoples R China
[3] Sichuan Univ, Inst Regulatory Sci Med Device, Chengdu 610064, Sichuan, Peoples R China
[4] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2025年 / 13卷 / 05期
基金：
国家重点研发计划;
关键词：
MEMBRANE-COATED NANOPARTICLES; THERAPY; THROMBOSIS; HYDROGEL;
D O I：
10.1039/d4tb02477j
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Platelets are nucleic-free cells with a lifespan of 7-10 days in the bloodstream, playing a crucial role in various physiological processes such as hemostasis, thrombus formation, tumor development and metastasis, inflammation, and host defense. By utilizing the unique structural and functional characteristics of platelets, platelet-modified nano-drugs can evade immune recognition and clearance and facilitate prolonged circulation in vivo, which ultimately allows the nanoparticles to reach sites of disease such as thrombi, tumors, inflammation, or bacterial infections, leading to specific adhesion and significantly enhancing the efficiency of targeted drug delivery. This paper reviews the novel design and application of platelet-derived biomaterials in various diseases in recent years and comprehensively demonstrates the potential of platelet-derived biomaterials in the fields of disease therapy and biodefence, which will provide a reference for advancing the development of platelet-derived biomaterials and clinical practice.
引用
收藏
页码：1573 / 1585
页数：13
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