N-Heterocyclic Carbene-Catalyzed [3+3] Annulation of Enals with Aminonaphthoquinones for the Synthesis of Functionalized Aza-anthraquinones

被引：2

作者：

Miao, Yuehua ^{[1
]}

Qi, Jing ^{[1
,2
]}

Li, Yanting ^{[1
]}

Pan, Ao ^{[1
]}

Duan, Xiao-Yong ^{[1
,2
]}

机构：

[1] Hebei Univ, Coll Chem & Mat Sci, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China

[2] Hebei Univ, Coll Chem & Mat Sci, State Key Lab New Pharmaceut Preparat & Excipients, Baoding 071002, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 22期

关键词：

DERIVATIVES; ACCESS;

D O I：

10.1021/acs.joc.4c01655

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rapid construction of functionalized aza-anthraquinones has been successfully developed via NHC-catalyzed formal [3 + 3] annulation of 2-aminoquinones with enals. This reaction features several advantages, such as readily available starting materials, mild reaction conditions, and flexible product transformations. The study on the atroposelective version of this strategy was also carried out, and several C-N axial chiral aza-anthraquinones were synthesized in moderate yields with moderate to good enantioselectivities.

引用

页码：16433 / 16443

页数：11

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