Occurrence of contaminants of emerging concern in different water samples from the lower part of the Danube River Middle Basin - A review

This study intends to assess the extent of the occurrence of CECs in different water types based on the literature data reported for the countries from a lower part of the Middle Danube Basin, including those belonging to the Western Balkan (WB) region and two upstream neighboring EU Member States, Croatia and Slovenia. These countries share main freshwater courses important for drinking water supply, agriculture, industry, navigation, tourism, etc, but in some of them there are low rate of wastewater treatment, impacting the chemical status of water resources in the region and probably beyond, if downstream countries are considered. The literature survey revealed 38 investigative studies reporting data on CECs in water matrices sampled in the region in the period 2008-2022. Surface water was the most frequently studied water type in WB countries, while wastewater was the dominant water type studied in Slovenia and Croatia. The most often analyzed compounds in the studies dealing with surface water and wastewater were the anti-epileptic drug carbamazepine, some non-steroidal antiinflammatory drugs, and antibiotics; pharmaceutically active compounds were also the most analyzed CECs in groundwater and drinking water. Additionally, similarities/dissimilarities among the experimental approaches in these studies were discussed in relation to the state-of-the-art research directions for the CECs surveillance in the European Union, resulting in summarized strengths and gaps in capacities for the wide-range surveillance of CECs in the lower part of the Middle Danube Basin. This is the first integral overview of the studies on CECs in waters from the countries belonging to this part of the Danube Basin, representing a valuable baseline for further enhancement of the relevant monitoring efforts and chemical status of the regional water resources, especially in countries with poor wastewater management.