Bioengineered Nanomaterials for siRNA Therapy of Chemoresistant Cancers

被引：2

作者：

Sanati, Mehdi ^{[1
]}

Figueroa-Espada, Christian G. ^{[2
]}

Han, Emily L. ^{[2
]}

Mitchell, Michael J. ^{[2
]}

Yavari, Saber Amin

机构：

[1] Birjand Univ Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, Birjand 97178, Iran

[2] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

来源：

ACS NANO | 2024年 / 18卷 / 51期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

chemoresistance; cancer; siRNA; nanotechnology; gene therapy; nanoparticles; drug delivery; chemotherapy; MESOPOROUS SILICA NANOPARTICLES; OVERCOME DRUG-RESISTANCE; IRON-OXIDE NANOPARTICLES; CHITOSAN-BASED NANOPARTICLES; MESENCHYMAL STEM-CELLS; SMALL INTERFERING RNA; P-GLYCOPROTEIN SIRNA; BREAST-CANCER; CO-DELIVERY; GOLD NANOPARTICLES;

D O I：

10.1021/acsnano.4c11259

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chemoresistance remains a long-standing challenge after cancer treatment. Over the last two decades, RNA interference (RNAi) has emerged as a gene therapy modality to sensitize cancer cells to chemotherapy. However, the use of RNAi, specifically small-interfering RNA (siRNA), is hindered by biological barriers that limit its intracellular delivery. Nanoparticles can overcome these barriers by protecting siRNA in physiological environments and facilitating its delivery to cancer cells. In this review, we discuss the development of nanomaterials for siRNA delivery in cancer therapy, current challenges, and future perspectives for their implementation to overcome cancer chemoresistance.

引用

页码：34425 / 34463

页数：39

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