Copper-Catalyzed Hydroamination of 2-Alkynylazobenzenes: Synthesis of 3-Alkenyl-2H-Indazoles

被引：0

作者：

Manas, Clara ^{[1
,2
]}

Herrero-Bourdieu, Juan ^{[1
]}

Merino, Estibaliz ^{[1
,2
]}

机构：

[1] Univ Alcala, Inst Invest Andres M Rio IQAR, Fac Farm, Dept Quim Organ & Quim Inorgan, Alcala De Henares 28805, Madrid, Spain

[2] Inst Ramon & Cajal Invest Sanitaria IRYCIS, Madrid 28034, Spain

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 22期

关键词：

SUBSTITUTED CINNOLINES; CYCLIZATION; COARCTATE; INDAZOLES; PSEUDOCOARCTATE; 2H-INDAZOLES; COMPLEXES;

D O I：

10.1021/acs.joc.4c02144

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed intramolecular synthesis of 3-alkenyl-2H-indazoles from 2-alkynylazobenzenes is described. The reaction proceeds in a single step via C-N bond formation and a subsequent 1,2-hydride shift, affording products in high yields. DFT calculations suggest the 1,2-hydride shift as the rate-determining step. Further derivatization enables functionalization of the 3-alkenyl-2H-indazoles.

引用

页码：16883 / 16888

页数：6

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