Enhanced electrochemical sensor based on Uio-66-NH2/carbon nanotubes hybrid for selective detection of ofloxacin

Metal-organic frameworks (MOFs) materials with adjustable properties are potential candidates in the field of electroanalysis. However, the typically poor electrical conductivity of MOFs limits their applications in electrochemical sensors. In this study, an enhanced conductivity UiO-66-NH2 was fabricated by introducing carboxylated carbon nanotubes (CNTs) and defective engineering (named as UiO-66-NH2/CNTs). The performance of electrochemical sensor constructing based on UiO-66-NH2/CNTs was characterized and evaluated by choosing ofloxacin (OFL) as a model analyte. A molecularly imprinted polymer (MIP) film for OFL was prepared by electropolymerization o-phenylenediamine onto electrode surface in the presence of OFL, which endows this sensor exceptional selectivity. Consequently, the UiO-66-NH2/CNTs@MIP modified ITO electrode displayed excellent sensing performance for OFL, with a wide linear response range (0.1 nM-20 mu M) and a low detection limit (0.03 nM). Furthermore, the sensor displayed superior selectivity, stability, and reproducibility. Evaluation of the sensor's performance in detecting OFL in actual drug samples yielded a well sensitivity, underscoring its outstanding practical utility.