S BOND FORMATION;
C-H BONDS;
QUINONE MONO-O;
S-ACETALS;
INDOLES;
INHIBITORS;
FUNCTIONALIZATION;
HYDRAZIDES;
SULFIDES;
ESTERS;
SALTS;
D O I:
10.1021/acs.joc.4c01819
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
A practical C3 sulfenylation of indoles has been accomplished using arenediazonium tosylates and sodium metabisulfite, with a key role of iodine/DMF combination in the reaction. The method involves scarce use of sodium metabisulfite as a divalent sulfur source and offers an array of structurally diverse 3-arylthioindoles in high yields under operationally simple transition-metal-free and mild conditions.