A water-soluble Gd(<sc>iii</sc>)-based fluorescence/T1-MR dual-modality probe for H2S sensing

被引:0
作者
Mak, Ho-Nam [1 ]
Lu, Xuanyi [2 ]
Pan, Siyu [2 ]
Gu, Yanjuan [1 ]
Jiang, Lijun [1 ,2 ]
Wong, Wing-Tak [1 ]
机构
[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China
[2] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China
基金
中国国家自然科学基金;
关键词
HYDROGEN-SULFIDE; RELAXIVITY;
D O I
10.1039/d4cc05042h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We present a water-soluble fluorescence/MR dual-modality probe NBD[Gd] for H2S detection. It showed 88.4% of fluorescence quenching and a 36% reduction in r1 upon exposure to H2S. It is readily uptaken by cells to sense the endogenous H2S. Besides providing a bimodal H2S imaging probe, our study also confirms the high H2S level in CT26 cells and its functional consequence in promoting cell growth.
引用
收藏
页码:14419 / 14422
页数:4
相关论文
共 27 条
[1]  
Cirino G, 2023, PHYSIOL REV, V103, P31, DOI 10.1152/physrev.00028.2021
[2]   Anti-inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H2S donors in COVID-19 therapy [J].
Citi, Valentina ;
Martelli, Alma ;
Brancaleone, Vincenzo ;
Brogi, Simone ;
Gojon, Gabriel ;
Montanaro, Rosangela ;
Morales, Guillermo ;
Testai, Lara ;
Calderone, Vincenzo .
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 177 (21) :4931-4941
[3]   Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents [J].
Clough, Thomas J. ;
Jiang, Lijun ;
Wong, Ka-Leung ;
Long, Nicholas J. .
NATURE COMMUNICATIONS, 2019, 10 (1)
[4]   Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species [J].
Fosnacht, Kaylin G. ;
Pluth, Michael D. .
CHEMICAL REVIEWS, 2024, 124 (07) :4124-4257
[5]   Near-Infrared Fluorescent Probe for H2S Detection: Will pH Affect the Intracellular Sensing? [J].
Guan, Xiaowen ;
Lu, Hua ;
Ge, Xiyang ;
Yin, Yiyan ;
Ouyang, Jin ;
Na, Na .
ACS SENSORS, 2022, 7 (08) :2483-2491
[6]   Highly efficient H2S scavengers via thiolysis of positively-charged NBD amines [J].
Ismail, Ismail ;
Chen, Zhuoyue ;
Sun, Lu ;
Ji, Xiuru ;
Ye, Haishun ;
Kang, Xueying ;
Huang, Haojie ;
Song, Haibin ;
Bolton, Sarah G. ;
Xi, Zhen ;
Pluth, Michael D. ;
Yi, Long .
CHEMICAL SCIENCE, 2020, 11 (30) :7823-7828
[7]   NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications [J].
Jiang, Chenyang ;
Huang, Haojie ;
Kang, Xueying ;
Yang, Liu ;
Xi, Zhen ;
Sun, Hongyan ;
Pluth, Michael D. ;
Yi, Long .
CHEMICAL SOCIETY REVIEWS, 2021, 50 (13) :7436-+
[8]  
Joshi A., 2024, Biosens. Bioelectron., V19
[9]   Hydrogen Sulfide Biology and Its Role in Cancer [J].
Khattak, Saadullah ;
Rauf, Mohd Ahmar ;
Khan, Nazeer Hussain ;
Zhang, Qian-Qian ;
Chen, Hao-Jie ;
Muhammad, Pir ;
Ansari, Mohammad Azam ;
Alomary, Mohammad N. ;
Jahangir, Muhammad ;
Zhang, Chun-Yang ;
Ji, Xin-Ying ;
Wu, Dong-Dong .
MOLECULES, 2022, 27 (11)
[10]   Optimizing the Relaxivity of MRI Probes at High Magnetic Field Strengths With Binuclear GdIII Complexes [J].
Leone, Loredana ;
Ferrauto, Giuseppe ;
Cossi, Maurizio ;
Botta, Mauro ;
Tei, Lorenzo .
FRONTIERS IN CHEMISTRY, 2018, 6