Advanced Preparation Methods and Biomedical Applications of Single-Atom Nanozymes

被引：1

作者：

Zhu, Chun-Nan ^{[1
,2
]}

Chen, Xin ^{[1
,2
]}

Xu, Yong-Qiang ^{[1
,2
,3
]}

Wang, Fei ^{[4
,5
]}

Zheng, Dong-Yun ^{[1
,2
]}

Liu, Chao ^{[1
,2
]}

Zhang, Xue-Hao ^{[3
]}

Yi, Yu ^{[3
]}

Cheng, Dong-Bing ^{[6
]}

机构：

[1] South Cent Minzu Univ, Coll Biomed Engn, Hubei Key Lab Med Informat Anal & Tumor Diag & Tre, Wuhan 430074, Peoples R China

[2] South Cent Minzu Univ, Key Lab Cognit Sci State Ethn Affairs Commiss, Wuhan 430074, Peoples R China

[3] Chinese Acad Sci, Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biol Effects Nanomat & Nanosafety, Ctr Excellence Nanosci, Beijing 100190, Peoples R China

[4] Univ York, Wentworth Coll, Dept Biol, Wentworth Way, York YO10 5DD, England

[5] Univ York, Wentworth Coll, Sch Nat Sci, Wentworth Way, York YO10 5DD, England

[6] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Hubei Key Lab Nanomed Neurodegenerat Dis, Wuhan 430070, Peoples R China

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2024年 / 10卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Single-atom catalysts; Metal nanoparticles; Fenton reaction; Biomedical application; MESOPOROUS SILICA; CATALYSTS;

D O I：

10.1021/acsbiomaterials.4c01530

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Metal nanoparticles with inherent defects can harness biomolecules to catalyze reactions within living organisms, thereby accelerating the advancement of multifunctional diagnostic and therapeutic technologies. In the quest for superior catalytic efficiency and selectivity, atomically dispersed single-atom nanozymes (SANzymes) have garnered significant interest recently. This review concentrates on the development of SANzymes, addressing potential challenges such as fabrication strategies, surface engineering, and structural characteristics. Notably, we elucidate the catalytic mechanisms behind some key reactions to facilitate the biomedical application of SANzymes. The diverse biomedical uses of SANzymes including in cancer therapy, wound disinfection, biosensing, and oxidative stress cytoprotection are comprehensively summarized, revealing the link between material structure and catalytic performance. Lastly, we explore the future prospects of SANzymes in biomedical fields.

引用

页码：7352 / 7371

页数：20

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