Exploring the crystallisation of aspirin in a confined porous material using solid-state nuclear magnetic resonance

被引：0

作者：

Juramy, Marie ^{[1
]}

Besson, Eric ^{[1
]}

Gastaldi, Stephane ^{[1
]}

Ziarelli, Fabio ^{[2
]}

Viel, Stephane ^{[1
,3
]}

Mollica, Giulia ^{[1
]}

Thureau, Pierre ^{[1
]}

机构：

[1] Aix Marseille Univ, CNRS, ICR, UMR 7273, F-13397 Marseille, France

[2] Aix Marseille Univ, Cent Marseille, CNRS, Federat Sci Chim FR 1739, F-13397 Marseille, France

[3] Inst Univ France, F-75005 Paris, France

来源：

FARADAY DISCUSSIONS | 2025年 / 255卷 / 00期

基金：

欧盟地平线“2020”;

关键词：

ENHANCED NMR-SPECTROSCOPY; FLEXIBLE MOLECULES; POLARIZATION; POLYMORPHISM; EFFICIENT; C-13; FORMS;

D O I：

10.1039/d4fd00123k

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this study, nuclear magnetic resonance (NMR) is used to investigate the crystallisation behaviour of aspirin within a mesoporous SBA-15 silica material. The potential of dynamic nuclear polarisation (DNP) experiments is also investigated using specifically designed porous materials that incorporate polarising agents within their walls. The formation of the metastable crystalline form II is observed when crystallisation occurs within the pores of the mesoporous structure. Conversely, bulk crystallisation yields the most stable form, namely form I, of aspirin. Remarkably, the metastable form II remains trapped within the pores of mesoporous SBA-15 silica material even 30 days after impregnation, underscoring its persistent stability within this confined environment. In this study, nuclear magnetic resonance (NMR) is used to investigate the crystallisation behaviour of aspirin within a mesoporous SBA-15 silica material.

引用

页码：483 / 494

页数：12