A systematic review on analytical methods of the neurotoxin β-N-methylamino-L-alanine (BMAA), and its causative microalgae and distribution in the environment

被引：0
作者：
Kim, Sea-Yong [1 ]
Kim, Mungi [2 ]
Park, Kiho [2 ]
Hong, Seongjin [1 ,2 ]
机构：
[1] Department of Marine Environmental Sciences & Institute of Marine Environmental Sciences, Chungnam National University, Daejeon
[2] Department of Earth, Environmental & Space Sciences, Chungnam National University, Daejeon
来源：
Chemosphere | 2024年 / 366卷
基金：
新加坡国家研究基金会;
关键词：
Aquatic ecosystems; BMAA; LC-MS/MS; Microalgae; Neurotoxin; Quality controls;
D O I：
10.1016/j.chemosphere.2024.143487
中图分类号：
学科分类号：
摘要：
β-N-Methylamino-L-alanine (BMAA), a neurotoxin produced by various microalgal groups, is associated with neurodegenerative diseases and is considered a major environmental factor potentially linked to sporadic amyotrophic lateral sclerosis. This study systematically reviews the analytical methods used to study BMAA in publications from 2019 to the present. It also investigates the causative microalgae of BMAA and its geographical distributions in aquatic ecosystems based on studies conducted since 2003. A comprehensive search using the Web of Science database revealed that hydrolysis for extraction (67%), followed by quantification using LC-MS/MS (LC: 84%; MS/MS: 88%), is the most commonly employed method in BMAA analysis. Among analytical methods, RPLC-MS/MS had the highest percentage (88%) of BMAA-positive results and included a high number of quality control (QC) assessments. Various genera of cyanobacteria and diatoms have been reported to produce BMAA. The widespread geographical distribution of BMAA across diverse ecosystems highlights significant environmental and public health concerns. Notably, BMAA accumulation and biomagnification are likely more potent in marine or brackish water ecosystems than in freshwater ecosystems, potentially amplifying its ecological impacts. Future research should prioritize advanced, sensitive methods, particularly LC-MS/MS with as many QC assessments as possible, and should expand investigations to identify novel microalgal producers and previously uncharted geographical areas, with a special focus on marine or brackish water ecosystems. This effort will enhance our understanding of the environmental distribution and impacts of BMAA. © 2024 Elsevier Ltd
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[1]  
Al-Sammak M.A., Hoagland K.D., Cassada D., Snow D.D., Co-Occurrence of the cyanotoxins BMAA, DABA and anatoxin-a in Nebraska reservoirs, fish, and aquatic plants, Toxins, 6, pp. 488-508, (2014)
[2]  
Almuhtaram H., Cui Y.J., Zamyadi A., Hofmann R., Cyanotoxins and cyanobacteria cell accumulations in drinking water treatment plants with a low risk of bloom formation at the source, Toxins, 10, (2018)
[3]  
Amzil Z., Derrien A., Terre Terrillon A., Savar V., Bertin T., Peyrat M., Duval A., Lhaute K., Arnich N., Hort V., Five years monitoring the emergence of unregulated toxins in shellfish in France (EMERGTOX 2018–2022), Mar. Drugs, 21, (2023)
[4]  
Banack S.A., Second laboratory validation of β-N-methylamino-L-alanine, N-(2aminoethyl) glycine, and 2, 4-diaminobuytric acid by ultra-performance liquid chromatography and tandem mass spectrometry, Neurotox. Res., 39, pp. 107-116, (2021)
[5]  
Banack S.A., Caller T., Henegan P., Haney J., Murby A., Metcalf J.S., Powell J., Cox P.A., Stommel E., Detection of cyanotoxins, β-N-methylamino-L-alanine and microcystins, from a lake surrounded by cases of amyotrophic lateral sclerosis, Toxins, 7, pp. 322-336, (2015)
[6]  
Banack S.A., Johnson H.E., Cheng R., Cox P.A., Production of the neurotoxin BMAA by a marine cyanobacterium, Mar. Drugs, 5, pp. 180-196, (2007)
[7]  
Banack S.A., Metcalf J.S., Bradley W.G., Cox P.A., Detection of cyanobacterial neurotoxin β-N-methylamino-L-alanine within shellfish in the diet of an ALS patient in Florida, Toxicon, 90, pp. 167-173, (2014)
[8]  
Baptista M.S., Cianca R.C., Lopes V.R., Almeida C.M.R., Vasconcelos V.M., Determination of the non protein amino acid β-N-methylamino-L-alanine in estuarine cyanobacteria by capillary electrophoresis, Toxicon, 58, pp. 410-414, (2011)
[9]  
Baptista M.S., Vasconcelos R.G.W., Ferreira P.C., Almeida C.M.R., Vasconcelos V.M., Assessment of the non-protein amino acid BMAA in Mediterranean mussel after feeding with estuarine cyanobacteria, Environ. Sci. Pollut. R., 22, pp. 12501-12510, (2015)
[10]  
Beach D.G., Kerrin E.S., Quilliam M.A., Selective quantitation of the neurotoxin BMAA by use of hydrophilic-interaction liquid chromatography–differential mobility spectrometry–tandem mass spectrometry (HILIC–DMS–MS/MS), Anal. Bioanal. Chem., 407, pp. 8397-8409, (2015)
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