Synthesis, and Characterization of Silver Nanoparticles Functionalized with a Chalcone for Potential Antioxidant Activity

被引：0
作者：
Mezoughi, Aysha B. [1 ]
Ettarhouni, Zaineb O. [1 ]
Abdussalam-Mohammed, Wanisa [2 ]
Alghzewi, Huda Abdalla [3 ]
Elbeshti, Hager Sadek [4 ]
Wanes, Safia Elaarf [1 ,5 ]
Farhat, Mahmoud F. [1 ]
机构：
[1] Chemistry Department, Faculty of Science, University of Tripoli, Tripoli
[2] Faculty of Engineering, University of Tripoli., Tripoli
[3] Biotechnology Research Center, Tripoli
[4] Department of Chemistry, Zawia University, Zawia
[5] Chemistry Department, Faculty of Education, Azzaytuna University, Tarhuna
来源：
Journal of Nano Research | 2024年 / 85卷
关键词：
anticancer; antioxidants; Chalcone; free radicals; Silver nanoparticles;
D O I：
10.4028/p-e0yQjG
中图分类号：
学科分类号：
摘要：
Silver nanoparticles (AgNPs) possess unusual optical, electrical, and catalytic properties. Hence, they are promising candidates in biomedical applications due to their shape and high surface area. Therefore, in present study, AgNPs were functionalized by using chalcone derivative as reducing and capping agent. The synthesized chalcone derivative was characterized by Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance (NMR), and mass spectroscopic techniques (MS). The resulting AgNPs were thoroughly characterized by different techniques, including ultraviolet-visible spectroscopy (UV-Vis), dynamic light scattering (DLS), transmission electron microscopy (TEM), and FTIR. The monodispersed AgNPs were produced with 49.5 ±6 nm diameter based on DLS results, and TEM results showed a spherical shape with a size of 30±5 nm. Also, the absorption peak at 394 nm in the UV-Vis spectrum confirmed the production of AgNPs. The biological applications of both chalcone derivative and AgNPs as antioxidant agents were evaluated. The obtained results were promising for the development of antioxidant drugs derived from silver nanoparticles functionalized chalcone derivative with hydroxy and methoxy substituents. © 2024, Trans Tech Publications Ltd. All rights reserved.
引用
收藏
页码：11 / 20
页数：9
相关论文
共 31 条
  • [1] Perez-Gonzalez A., Castaneda-Arriaga R., Hernandez-Ayala L. F., Galano A., Chalcone Derivatives with a High Potential as Multifunctional Antioxidant Neuroprotectors, ACS Omega, 7, pp. 38254-38268, (2022)
  • [2] Erenler R., Meral B., Sen O., Elmastas M., Aydin A., Eminagaoglu O., Topc G., Bioassay-guided isolation, identification of compounds from Origanum rotundifolium and investigation of their antiproliferative and antioxidant activities, Pharmaceutical Biology, 55, pp. 1646-1653, (2017)
  • [3] Khan R. A., Khan M. R., Sahreen S., Ahmed M., Assessment of flavonoids contents and in vitro antioxidant activity of Launaea procumbens, Chemistry Central Journal, 43, pp. 1-11, (2012)
  • [4] Mezoughi A. B., Costanzo C. M., Parker G. M., Behiry E. M., Scott A., Wood A. C., Adams S. E., The Lysozyme Inhibitor Thionine Acetate Is Also an Inhibitor of the Soluble Lytic Transglycosylase Slt35 from Escherichia coli, Molecules, 26, (2021)
  • [5] Nie Z., Liu K. J., Zhong C-J, Wang L-F, Yang Y., Tian Q., Enhanced radical scavenging activity by antioxidant-functionalized gold nanoparticles: A novel inspiration for development of new artificial antioxidants, Free Radical Biology & Medicine, 43, pp. 1243-1254, (2007)
  • [6] Hwang I., Hwang J.H., Choi H., Kim K., Lee D.G., Synergistic effects between silver nanoparticles and antibiotics and the mechanisms involved, 61, pp. 1719-1726, (2012)
  • [7] Ernest V., Shiny P.J., Mukherjee A., Chandrasekaran N., Silver nanoparticles: a potential nanocatalyst for the rapid degradation of starch hydrolysis by a-amylase, Carbohydrate Research, 352, pp. 60-64, (2012)
  • [8] Ahmadian E., Maleki S., Rahimpour E., Hasanzadeh A., Effect of silver nanoparticles in the induction of apoptosis on human hepatocellular carcinoma (HepG2) cell line, Materials Science & Engineering C, 93, pp. 465-471, (2018)
  • [9] Bruna T., Maldonado-Bravo F., Jara P., Caro N., Silver nanoparticles and their antibacterial applications, International Journal of Molecular Sciences, 22, (2021)
  • [10] Yin I.X., Zhang J., Zhao I.S., Mei M.L., Li Q., Zhao I.S., Mei M.L., The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry, (2023)
1234