Design, construction, and test of compact, distributed-charge, X-band accelerator systems that enable image-guided, VHEE FLASH radiotherapy

被引：1

作者：

Barty, Christopher P. J. ^{[1
,2
,3
]}

Algots, J. Martin ^{[1
]}

Amador, Alexander J. ^{[1
]}

Barty, James C. R. ^{[1
]}

Betts, Shawn M. ^{[1
]}

Castaneda, Marcelo A. ^{[1
]}

Chu, Matthew M. ^{[1
]}

Daley, Michael E. ^{[1
]}

Lopez, Ricardo A. De Luna ^{[1
]}

Diviak, Derek A. ^{[1
]}

Effarah, Haytham H. ^{[1
,2
,3
]}

Feliciano, Roberto ^{[1
]}

Garcia, Adan ^{[1
]}

Grabiel, Keith J. ^{[1
]}

Griffin, Alex S. ^{[1
]}

Hartemann, Frederic V. ^{[1
]}

Heid, Leslie ^{[1
,2
]}

Hwang, Yoonwoo ^{[1
]}

Imeshev, Gennady ^{[1
]}

Jentschel, Michael ^{[1
]}

Johnson, Christopher A. ^{[1
]}

Kinosian, Kenneth W. ^{[1
]}

Lagzda, Agnese ^{[1
]}

Lochrie, Russell J. ^{[1
]}

May, Michael W. ^{[1
]}

Molina, Everardo ^{[1
]}

Nagel, Christopher L. ^{[1
]}

Nagel, Henry J. ^{[1
]}

Peirce, Kyle R. ^{[1
]}

Peirce, Zachary R. ^{[1
]}

Quinonez, Mauricio E. ^{[1
]}

Raksi, Ferenc ^{[1
]}

Ranganath, Kelanu ^{[1
]}

Reutershan, Trevor ^{[1
,2
,3
]}

Salazar, Jimmie ^{[1
]}

Schneider, Mitchell E. ^{[1
]}

Seggebruch, Michael W. L. ^{[1
,2
]}

Yang, Joy Y. ^{[1
]}

Yeung, Nathan H. ^{[1
]}

Zapata, Collette B. ^{[1
]}

Zapata, Luis E. ^{[1
]}

Zepeda, Eric J. ^{[1
]}

Zhang, Jingyuan ^{[1
]}

机构：

[1] Lumitron Technol Inc, Irvine, CA 92617 USA

[2] Univ Calif Irvine, Phys & Astron Dept, Irvine, CA 92697 USA

[3] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Irvine, CA 92617 USA

来源：

FRONTIERS IN PHYSICS | 2024年 / 12卷

关键词：

lasers; x-rays; laser-Compton scattering; accelerators; X-band; flash; high-resolution radiography; VHEE; INVERSE COMPTON-SCATTERING; HIGH-ENERGY ELECTRONS; THOMSON-SCATTERING; RADIATION-THERAPY; OPTICAL RADIATION; FILM MEASUREMENTS; PHOTON; LIGHT; PULSE; PLEIADES;

D O I：

10.3389/fphy.2024.1472759

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The design and optimization of laser-Compton x-ray systems based on compact distributed charge accelerator structures can enable micron-scale imaging of disease and the concomitant production of beams of Very High Energy Electrons (VHEEs) capable of producing FLASH-relevant dose rates ( similar to 10 Gy in less than 100 ns). The physics of laser-Compton x-ray scattering ensures that the x-rays produced by this process follow exactly the trajectory of the electrons from which the x-rays were produced, thus providing a route to not only compact VHEE radiotherapy but also image-guided, VHEE FLASH radiotherapy. This manuscript will review the compact accelerator architecture considerations that simultaneously optimize the production of laser-Compton x-rays from the collision of energetic laser pulses with high energy electrons and the production of high-bunch-charge VHEEs. The primary keys to this optimization are use of X-band RF accelerator structures which have been demonstrated to operate with over 100 MeV/m acceleration gradients. The operation of these structures in a distributed charge mode in which each radiofrequency (RF) cycle of the drive RF pulse is filled with a low-charge, high-brightness electron bunch is enabled by the illumination of a high-brightness photogun with a train of UV laser pulses synchronized to the frequency of the underlying accelerator system. The UV pulse trains are created by a patented pulse synthesis approach which utilizes the RF clock of the accelerator to phase and amplitude modulate a narrow band continuous wave (CW) seed laser. In this way it is possible to produce up to 10 mu A of average beam current from the accelerator. Such high current from a compact accelerator enables production of sufficient x rays via laser-Compton scattering for clinical imaging and does so from a machine of "clinical" footprint. At the same time, the production of 1,000 or greater individual micro-bunches per RF pulse enables > 10 nC of charge to be produced in a macrobunch of < 100 ns. The design, construction, and test of the 100-MeV class prototype system in Irvine, CA is also presented.

引用

页数：18

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