Cuproptosis in cancer therapy: mechanisms, therapeutic application and future prospects

被引：0

作者：

Hu, Jiawei ^{[1
,3
]}

Zhu, Junfei ^{[2
]}

Chen, Tao ^{[1
,3
]}

Zhao, Yudie ^{[1
,3
]}

Xu, Qingwen ^{[1
,3
]}

Wang, Yan ^{[1
,3
]}

机构：

[1] Wannan Med Coll, Yijishan Hosp, Affiliated Hosp 1, Dept Pharm, Wuhu, Peoples R China

[2] China Japan Friendship Hosp, 2 Sakura East St, Beijing, Peoples R China

[3] Wannan Med Coll, Dept Pharm, Wuhu, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2024年 / 12卷 / 47期

关键词：

OXIDATIVE STRESS; REPURPOSING-DISULFIRAM; CELL-DEATH; COPPER; MITOCHONDRIA; INHIBITION; ELESCLOMOL; DRUG; METABOLISM; RESISTANCE;

D O I：

10.1039/d4tb01877j

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Cuproptosis is a regulated form of cell death induced by the accumulation of metal ions and is closely linked to aspects of cellular drug resistance, cellular metabolism, and signalling pathways. Due to its crucial role in regulating physiological and pathological processes, cuproptosis has gained increasing significance as a potential target for anticancer drug development. In this review, we introduce the definition of cuproptosis and provide a comprehensive discussion of the mechanisms of cuproptosis. In addition, the methods for the detection of cuproptosis are summarized, and recent advances in cuproptosis in cancer therapy are reviewed, mainly in terms of elesclomol (ES)-mediated cuproptosis and disulfiram (DSF)-mediated cuproptosis, which provided practical value for applications. Finally, the current challenges and future development of cuproptosis-mediated cancer therapy are discussed. In summary, this review highlights recent progress on cuproptosis in cancer therapy, offering novel ideas and strategies for future research and applications.

引用

页码：12191 / 12206

页数：16

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