This paper presents both experimental and numerical investigations into the edge-on impact behavior of T700/ YPH307 composite laminates with varying lay-up designs and impact energy levels. Various non-destructive testing techniques, including visual inspection, ultrasonic C-scanning and X-ray computed tomography (CT), were used to detect the post-impact damage status and further reveal its 3D spatial distribution. A continuum damage mechanics (CDM) model, incorporating in-plane shear nonlinearity, fracture plane angle within anisotropic materials, as well as fiber kinking failure in longitudinal compression, was established using an explicit solver. Detailed comparison of the experimental and numerical results was conducted in mechanical response curves and failure mechanisms, where a good agreement was observed. Parameter analyses on the in-situ strengths and the friction coefficient were also performed, offering guidelines for the edge-on impact modelling. Failure mechanisms induced by edge-on impact typically exhibit two distinct features: a highly localized debris wedge, which can be regarded as a trigger in the subsequent occurrence of damage, and the bending fracture of the outer plies resulting from the wedge effect during the oscillating stage of an impact force plateau. Besides, higher impact energy exacerbated internal damage, while the influence of the lay-ups was relatively limited.