Ligand-Enabled Gold-Catalyzed Cyanation of Organohalides

被引：5
|
作者：
Kumar, Anil [1 ]
Bhattacharya, Nandita [1 ]
Mane, Manoj V. [2 ]
Patil, Nitin T. [1 ]
机构：
[1] Indian Inst Sci Educ & Res Bhopal, Dept Chem, Bhopal Bypass Rd, Bhopal 462066, India
[2] Jain Deemed Univ, Ctr Nano & Mat Sci, Jain Global Campus, Bangalore 562112, Karnataka, India
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2024年 / 63卷 / 47期
关键词：
gold; redox catalysis; C(sp(2))-CN coupling; cross-coupling; gold-cyanide; VISIBLE-LIGHT PHOTOREDOX; CROSS-COUPLING REACTIONS; REDUCTIVE ELIMINATION; OXIDATIVE ADDITION; CONVENIENT; COMPLEXES; ARYLATION; CYANIDE; ALKYNES; SALTS;
D O I：
10.1002/anie.202412682
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we disclose the first report on gold-catalyzed C(sp(2))-CN cross-coupling reaction by employing a ligand-enabled Au(I)/Au(III) redox catalysis. This transformation utilizes acetone cyanohydrin as a nucleophilic cyanide source to convert simple aryl and alkenyl iodides into the corresponding nitriles. Combined experimental and computational studies highlighted the crucial role of cationic silver salts in activating the stable (P,N)-AuCN complex towards the oxidative addition of aryl iodides to subsequently generate key aryl-Au(III) cyanide complexes.
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页数：7
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