Crafting nature's wonders: nanoarchitectonics developments in bioinspired nanocellulose-based stimuli-responsive supramolecular matrices

Stimuli-responsive supramolecular assemblies have recently gained extensive attention in the biomedical field. Research focusing mainly on bioinspired functional supramolecular materials has shown great promise for potential drug delivery applications. Such materials can be engineered into 'smart' materials by utilizing various external stimuli such as pH, heat, light, and magnetic fields. Combining stimuli-responsive properties with bioinspired and biodegradable nanocellulose as a supramolecular matrix can offer a synergistic strategy for targeted and on-demand delivery of therapeutic drugs. The limitations of traditional drug delivery techniques may be greatly mitigated using this combination. In this review, we aim to provide a comprehensive overview of the recent advances in the development of stimuli-responsive nanocellulose-based drug delivery systems. Finally, we have highlighted the current challenges and future perspectives in the field, emphasizing the need for further research to overcome existing barriers and fully realize the potential of stimuli-responsive nanocellulose in drug-releasing applications. Reviewing the state-of-the-art developments and identifying critical areas for future exploration will provide valuable insights for researchers and practitioners working in nanomedicine and drug delivery, fostering the advancement of innovative and effective drug-releasing technologies.