Molecular recognition of peptides and proteins by cucurbit[n]urils: systems and applications

被引：9

作者：

Armstrong, Lilyanna ^{[1
]}

Chang, Sarah L. ^{[1
]}

Clements, Nia ^{[1
]}

Hirani, Zoheb ^{[1
]}

Kimberly, Lauren B. ^{[1
]}

Odoi-Adams, Keturah ^{[2
]}

Suating, Paolo ^{[1
]}

Taylor, Hailey F. ^{[1
]}

Trauth, Sara A. ^{[1
]}

Urbach, Adam R. ^{[1
]}

机构：

[1] Trinity Univ, Dept Chem, San Antonio, TX 78212 USA

[2] Southwestern Oklahoma State Univ, Dept Chem & Phys, Weatherford, OK 73096 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2024年 / 53卷 / 23期

基金：

美国国家卫生研究院;

关键词：

SUPRAMOLECULAR POLYMER; AMINO-ACIDS; COVALENT CONDENSATION; SUSTAINED-RELEASE; AQUEOUS-SOLUTION; ENZYME ASSAYS; AFFINITY TAGS; HOST; BINDING; COMPLEXES;

D O I：

10.1039/d4cs00569d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of methodology for attaching ligand binding sites to proteins of interest has accelerated biomedical science. Such protein tags have widespread applications as well as properties that significantly limit their utility. This review describes the mechanisms and applications of supramolecular systems comprising the synthetic receptors cucurbit[7]uril (Q7) or cucurbit[8]uril (Q8) and their polypeptide ligands. Molecular recognition of peptides and proteins occurs at sites of 1-3 amino acids with high selectivity and affinity via several distinct mechanisms, which are supported by extensive thermodynamic and structural studies in aqueous media. The commercial availability, low cost, high stability, and biocompatibility of these synthetic receptors has led to the development of myriad applications. This comprehensive review compiles the molecular recognition studies and the resulting applications with the goals of providing a valuable resource to the community and inspiring the next generation of innovation.

引用

页码：11519 / 11556

页数：38

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