Oudemansiella radicata polysaccharides alleviated LPS-induced liver damage via regulating TLR4/NF-κB and Bax/Bcl-2 signaling pathways

被引：1
作者：
Chen, Peiying [1 ,2 ]
Li, Xiaoxu [1 ]
Zhang, Yiwen [1 ]
Wang, Houpeng [2 ]
Yu, Yunke [1 ]
Wu, Chao [1 ]
Jia, Le [1 ,2 ]
Zhang, Jianjun [1 ,2 ]
机构：
[1] Shandong Agr Univ, Coll Life Sci, Tai An 271018, Peoples R China
[2] Shandong Ocean Agr Dev Co LTD, Jining 272600, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 282卷
关键词：
Oudemansiella radicata polysaccharides; LPS-induced liver damage; TLR4/NF-kappa B signaling pathways; Bax/Bcl-2 signaling pathways; MYCELIA SELENIUM POLYSACCHARIDES; IN-VITRO; ANTI-INFLAMMATION; KAPPA-B; INHIBITION; INJURY; ANTIOXIDANT; ACTIVATION; MICE;
D O I：
10.1016/j.ijbiomac.2024.137370
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The study was aimed to develop natural non-toxic substances to prevent LPS-induced liver damages and its complications. In present work, a pyranose polysaccharide of Oudemansiella radicata polysaccharides (ORP) with typical characteristics of alpha-type glycosidic linkage was isolated from the O. radicata fruiting body by physicochemical analysis, and the potential impact against LPS-induced liver damage were performed in mice model. The results demonstrated that ORP showed significant hepatoprotective effects through its potential antioxidative, anti-inflammatory and anti-apoptosis activities via regulating the TLR4/NF-kappa B and Bax/Bcl-2 signaling pathway, independently or synergistically. These findings had established a robust theoretical framework for promoting the comprehensive utilization of ORP as supplements in the development of functional foods or drugs targeting LPS-induced liver damage and its associated complications.
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页数：11
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