In response to the difficult to integrate of füll lifecycle data, difficult to quantify of health predicr tion and evaluation, difficult to optimise of maintenance decisions, and difficult to generalise of System plat-forms in thc prognostics and health management (PHM) of large rotating machinery, cloud native thinking is in_ troduced, containerization technology and microservice architecture are adopted, and an open universal architec-ture of the System Software for PHM of large rotating machinery. The universal platform of System Software for PHM of large-scale rotating machinery is developed, including a hackend universal development engine and per-sonalized customized application programming interface (API) interface for the front end. The 1 + 3 agile cus-tomized development strategy of application Software for PHM of large rotating machinery has been proposed, which based on a universal platform, and integrated three key aspects: data access of application objeets, encap-sulation and deployment of algorithmic models, and visualization design, to achieve agile development of application Software for PHM of large rotating machinery. By adopting an open and wimwin approach, more model algorithm developers can partieipate in building bank of algorithm for PHM, and utilizing the collaborative mechanism of System Software to solve the challenge of integrating data throughout the entire lifecycle, the foun-dation for construeting ecosystem of application Software developing of PHM for large-scale rotary machinery will be laid. © 2024 Nanjing University of Aeronautics an Astronautics. All rights reserved.